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Clinical & Experimental Allergy:婴儿肠道微生物群可作为未来疾病生物标志物

2015-03-09 徐媛媛 MedSci原创

一项来自加拿大的新研究表明婴儿肠道细菌的变化可能会影响过敏性疾病或患哮喘病的发展。 这项研究发表在2月出版的Clinical & Experimental Allergy 期刊,”在三个月大的婴儿肠道中有少量的不同种类的细菌很有可能会在一岁的时候发展成为食物致敏如对牛奶、鸡蛋、花生等食物。和正常儿童相比发展成食物过敏性儿童肠道中也会存在两个特定类型的细菌--肠杆菌科、类杆菌。 使用皮肤

一项来自加拿大的新研究表明婴儿肠道细菌的变化可能会影响过敏性疾病或患哮喘病的发展。

这项研究发表在2月出版的Clinical & Experimental Allergy 期刊,”在三个月大的婴儿肠道中有少量的不同种类的细菌很有可能会在一岁的时候发展成为食物致敏如对牛奶、鸡蛋、花生等食物。和正常儿童相比发展成食物过敏性儿童肠道中也会存在两个特定类型的细菌--肠杆菌科、类杆菌。

使用皮肤点刺液对来自加拿大研究所166名婴儿进行食物致敏源筛查。粪便样本来自3个月和12个月大的婴儿。使用Illumina 16s rRNA测序技术来检测微生物群特点。

这项研究由加拿大卫生研究院资助的研究使用皮肤点刺液对166名婴儿进行食物致敏源筛查。这个具有里程碑意义的研究涉及超过3500个家庭和他们的新生儿,他正在密切监测,以确定遗传和家庭环境因素,有助于未来的过敏和哮喘。

“我们正在继续研究这一过程,”科研者Meghan Azad说道。“最终,我们希望开发新的方法来预防或治疗过敏,可能会通过修改肠道微生物群来实现。”

研究人员说,婴儿期的肠道细菌的数据可以作为未来疾病的生物标志物。

也有研究员警告说,“结果并不意味着孩子将来会发展成为完全的食物过敏。研究人员也将会扩大样本量数据希望最终将有超过2500名儿童的数据用于追踪他们成长,再次检测当他们成长到3岁和5岁时候的结果。

原始出处

M. B. Azad, T. Konya, D. S. Guttman, C. J. Field, M. R. Sears, K. T. HayGlass, P. J. Mandhane, S. E. Turvey, P. Subbarao, A. B. Becker, J. A. Scott, A. L. Kozyrskyj. Infant gut microbiota and food sensitization: associations in the first year of life. Clinical & Experimental Allergy, 2015; 45 (3): 632 DOI: 10.1111/cea.12487

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    2016-02-07 wjxue1988

    距离成功遥远

    0

  2. 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    2015-05-30 lixiaol
  3. 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createdName=feather89, createdTime=Mon May 18 07:04:00 CST 2015, time=2015-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824594, encodeId=54f918245943e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Nov 23 08:04:00 CST 2015, time=2015-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785926, encodeId=bc1c1e85926b5, content=<a href='/topic/show?id=bd0de16748' target=_blank style='color:#2F92EE;'>#experimental#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7167, encryptionId=bd0de16748, topicName=experimental)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cfa576, createdName=wfang545, createdTime=Thu Jul 02 16:04:00 CST 2015, time=2015-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785920, encodeId=cbd11e859207a, content=<a href='/topic/show?id=6a8ce16695' target=_blank style='color:#2F92EE;'>#Experiment#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7166, encryptionId=6a8ce16695, topicName=Experiment)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Tue Sep 08 21:04:00 CST 2015, time=2015-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=21058, encodeId=e48421058d6, content=研究热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Sun Apr 12 16:58:00 CST 2015, time=2015-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298825, encodeId=41a21298825c4, content=<a href='/topic/show?id=2088816e487' target=_blank style='color:#2F92EE;'>#肠道微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81674, encryptionId=2088816e487, topicName=肠道微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Wed Mar 11 03:04:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1328871, encodeId=94b813288e1f7, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Mar 11 03:04:00 CST 2015, time=2015-03-11, status=1, ipAttribution=)]
    2015-05-18 feather89
  5. [GetPortalCommentsPageByObjectIdResponse(id=63531, encodeId=99f4635312f, content=距离成功遥远 <br> , beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b44c94797, createdName=wjxue1988, createdTime=Sun Feb 07 01:59:00 CST 2016, time=2016-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951981, encodeId=ba2b1951981e8, content=<a href='/topic/show?id=04fa11552da' target=_blank style='color:#2F92EE;'>#Mental#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11552, encryptionId=04fa11552da, topicName=Mental)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Sat May 30 13:04:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840831, encodeId=ddb51840831bd, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Dec 05 10:04:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725774, encodeId=f6a21e257745d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon May 18 07:04:00 CST 2015, time=2015-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824594, encodeId=54f918245943e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Nov 23 08:04:00 CST 2015, time=2015-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785926, encodeId=bc1c1e85926b5, content=<a href='/topic/show?id=bd0de16748' target=_blank style='color:#2F92EE;'>#experimental#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7167, encryptionId=bd0de16748, topicName=experimental)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cfa576, createdName=wfang545, createdTime=Thu Jul 02 16:04:00 CST 2015, time=2015-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785920, encodeId=cbd11e859207a, content=<a href='/topic/show?id=6a8ce16695' target=_blank style='color:#2F92EE;'>#Experiment#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7166, encryptionId=6a8ce16695, topicName=Experiment)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Tue Sep 08 21:04:00 CST 2015, time=2015-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=21058, encodeId=e48421058d6, content=研究热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Sun Apr 12 16:58:00 CST 2015, time=2015-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298825, encodeId=41a21298825c4, content=<a href='/topic/show?id=2088816e487' target=_blank style='color:#2F92EE;'>#肠道微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81674, encryptionId=2088816e487, topicName=肠道微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Wed Mar 11 03:04:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1328871, encodeId=94b813288e1f7, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Mar 11 03:04:00 CST 2015, time=2015-03-11, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=63531, encodeId=99f4635312f, content=距离成功遥远 <br> , beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b44c94797, createdName=wjxue1988, createdTime=Sun Feb 07 01:59:00 CST 2016, time=2016-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951981, encodeId=ba2b1951981e8, content=<a href='/topic/show?id=04fa11552da' target=_blank style='color:#2F92EE;'>#Mental#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11552, encryptionId=04fa11552da, topicName=Mental)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Sat May 30 13:04:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840831, encodeId=ddb51840831bd, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Dec 05 10:04:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725774, encodeId=f6a21e257745d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon May 18 07:04:00 CST 2015, time=2015-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824594, encodeId=54f918245943e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Nov 23 08:04:00 CST 2015, time=2015-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785926, encodeId=bc1c1e85926b5, content=<a href='/topic/show?id=bd0de16748' target=_blank style='color:#2F92EE;'>#experimental#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7167, encryptionId=bd0de16748, topicName=experimental)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cfa576, createdName=wfang545, createdTime=Thu Jul 02 16:04:00 CST 2015, time=2015-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785920, encodeId=cbd11e859207a, content=<a href='/topic/show?id=6a8ce16695' target=_blank style='color:#2F92EE;'>#Experiment#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7166, encryptionId=6a8ce16695, topicName=Experiment)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Tue Sep 08 21:04:00 CST 2015, time=2015-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=21058, encodeId=e48421058d6, content=研究热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Sun Apr 12 16:58:00 CST 2015, time=2015-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298825, encodeId=41a21298825c4, content=<a href='/topic/show?id=2088816e487' target=_blank style='color:#2F92EE;'>#肠道微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81674, encryptionId=2088816e487, topicName=肠道微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Wed Mar 11 03:04:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1328871, encodeId=94b813288e1f7, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Mar 11 03:04:00 CST 2015, time=2015-03-11, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=63531, encodeId=99f4635312f, content=距离成功遥远 <br> , beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b44c94797, createdName=wjxue1988, createdTime=Sun Feb 07 01:59:00 CST 2016, time=2016-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951981, encodeId=ba2b1951981e8, content=<a href='/topic/show?id=04fa11552da' target=_blank style='color:#2F92EE;'>#Mental#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11552, encryptionId=04fa11552da, topicName=Mental)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Sat May 30 13:04:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840831, encodeId=ddb51840831bd, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sat Dec 05 10:04:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725774, encodeId=f6a21e257745d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon May 18 07:04:00 CST 2015, time=2015-05-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824594, encodeId=54f918245943e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Nov 23 08:04:00 CST 2015, time=2015-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785926, encodeId=bc1c1e85926b5, content=<a href='/topic/show?id=bd0de16748' target=_blank style='color:#2F92EE;'>#experimental#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7167, encryptionId=bd0de16748, topicName=experimental)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cfa576, createdName=wfang545, createdTime=Thu Jul 02 16:04:00 CST 2015, time=2015-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785920, encodeId=cbd11e859207a, content=<a href='/topic/show?id=6a8ce16695' target=_blank style='color:#2F92EE;'>#Experiment#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7166, encryptionId=6a8ce16695, topicName=Experiment)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Tue Sep 08 21:04:00 CST 2015, time=2015-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=21058, encodeId=e48421058d6, content=研究热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Sun Apr 12 16:58:00 CST 2015, time=2015-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298825, encodeId=41a21298825c4, content=<a href='/topic/show?id=2088816e487' target=_blank style='color:#2F92EE;'>#肠道微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81674, encryptionId=2088816e487, topicName=肠道微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Wed Mar 11 03:04:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1328871, encodeId=94b813288e1f7, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Mar 11 03:04:00 CST 2015, time=2015-03-11, status=1, ipAttribution=)]
    2015-09-08 qjddjq
  8. 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encryptionId=bd0de16748, topicName=experimental)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cfa576, createdName=wfang545, createdTime=Thu Jul 02 16:04:00 CST 2015, time=2015-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785920, encodeId=cbd11e859207a, content=<a href='/topic/show?id=6a8ce16695' target=_blank style='color:#2F92EE;'>#Experiment#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7166, encryptionId=6a8ce16695, topicName=Experiment)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Tue Sep 08 21:04:00 CST 2015, time=2015-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=21058, encodeId=e48421058d6, content=研究热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Sun Apr 12 16:58:00 CST 2015, time=2015-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298825, encodeId=41a21298825c4, content=<a href='/topic/show?id=2088816e487' target=_blank style='color:#2F92EE;'>#肠道微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81674, encryptionId=2088816e487, topicName=肠道微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Wed Mar 11 03:04:00 CST 2015, time=2015-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1328871, encodeId=94b813288e1f7, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Wed Mar 11 03:04:00 CST 2015, time=2015-03-11, status=1, ipAttribution=)]
    2015-04-12 223.104.5.**

    研究热点

    0

  9. 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encryptionId=bd0de16748, topicName=experimental)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cfa576, createdName=wfang545, createdTime=Thu Jul 02 16:04:00 CST 2015, time=2015-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785920, encodeId=cbd11e859207a, content=<a href='/topic/show?id=6a8ce16695' target=_blank style='color:#2F92EE;'>#Experiment#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7166, encryptionId=6a8ce16695, topicName=Experiment)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Tue Sep 08 21:04:00 CST 2015, time=2015-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=21058, encodeId=e48421058d6, content=研究热点, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, 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  10. 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    2015-03-11 膀胱癌

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9月24日,Nature Communications上发表的一篇论文提出,抗氧化剂Tempol通过改变小肠微生物群来降低小鼠的肥胖。这项研究提出了肠道微生物群在药物作用和体重调控中都有所涉及的另一个例子,同时也揭示了小肠中一个可能会被证明是减肥药物有用目标的信号通道。【原文下载】 Frank Gonzalez及同事用Tempol对小鼠进行处理,并在小肠里的主要微生物群中检测到一个变化。这一变化

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