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J Periodontal Res:PIN1或可促进牙周组织的再生

2017-04-24 MedSci MedSci原创

虽然研究已经表明骨组织中可表达肽酰脯氨酰顺/反异构酶(PIN1),但是PIN1在牙周组织和细胞中的确切作用目前尚不清楚。 本研究旨在阐明PIN1在牙周组织中的作用,在牙周组织和细胞中的表达,对体外培养成骨细胞分化的影响,并探究其潜在的信号转导机制。 结果显示,PIN1成功的在小鼠牙周组织(包括牙周膜细胞(PDLC)、成牙骨质细胞以及成骨细胞)中表达。靶向PIN1抑制剂胡桃醌并通过RNA

虽然研究已经表明骨组织中可表达肽酰脯氨酰顺/反异构酶(PIN1),但是PIN1在牙周组织和细胞中的确切作用目前尚不清楚。

本研究旨在阐明PIN1在牙周组织中的作用,在牙周组织和细胞中的表达,对体外培养成骨细胞分化的影响,并探究其潜在的信号转导机制。

结果显示,PIN1成功的在小鼠牙周组织(包括牙周膜细胞(PDLC)、成牙骨质细胞以及成骨细胞)中表达。靶向PIN1抑制剂胡桃醌并通过RNA干扰形成基因沉默可促进PDLCs和成牙骨质细胞中成骨细胞的分化,但是可抑制Pin1的过表达。此外,PIN1 siRNA提高了成骨细胞介质诱导的AMPK、mTOR、AKT、ERK的激活,以及p38和NF-κB通路,但是却降低了PIN1的过表达。PIN1 siRNA可诱导Runx2的表达,而PIN1的过表达则会下降Runx2的表达。

总之,本研究首次发现PIN1可在发育中的牙周组织中,以及体外培养的PDLCs和成牙骨质细胞中表达。抑制PIN1可刺激成骨细胞的分化,从而可能在牙周组织再生中发挥重要的作用。

原始出处:

Park KH, Cho EH, Bae WJ, et al. Role of PIN1 on in vivo periodontal tissue and in vitro cells. J Periodontal Res. 2017 Feb 15. doi: 10.1111/jre.12430.

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    2017-10-06 feather89
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    2017-06-21 zhangyxzsh
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    2017-04-24 shaosai

    好好学习,涨知识

    0

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