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Ann Oncol:多吃水果和蔬菜远离肺癌

2015-10-23 徐媛 MedSci原创

肺癌是癌症死亡最常见原因。水果和蔬菜中含有类胡罗卜素和其它抗氧化物质认为具有降低肺癌的风险。世界癌症研究基金会就针对这一问题进行了一项系统性综述和前瞻性研究的荟萃分析。研究人员通过PubMed等数据库进行了相关研究的检索,时间截止到2014年12月。研究人员通过最高、最低摄入量与剂量-应答来评估相对风险(RRs)和95% 置信区间(CIs),并校验可能的非线性相关。研究人员将最高摄入量与最低摄入量

肺癌是癌症死亡最常见原因。水果和蔬菜中含有类胡罗卜素和其它抗氧化物质认为具有降低肺癌的风险。世界癌症研究基金会就针对这一问题进行了一项系统性综述和前瞻性研究的荟萃分析。

研究人员通过PubMed等数据库进行了相关研究的检索,时间截止到2014年12月。研究人员通过最高、最低摄入量与剂量-应答来评估相对风险(RRs)和95% 置信区间(CIs),并校验可能的非线性相关。



研究人员将最高摄入量与最低摄入量相比,水果和蔬菜的合并RR为0.86 [95% CI 0.78–0.94; n (研究) = 18],蔬菜为0.92 (95% CI 0.87–0.97; n = 25),水果为0.82 (95% CI 0.76–0.89; n = 29)。水果和蔬菜摄入量,与之前吸烟或者从不吸烟者中呈负相关,但不显著。如果摄入量每天每增加100g,剂量-应答的呈显著性负相关性:水果和蔬菜RR为0.96(95% CI 0.94–0.98, I2=64%, n=14, N =9609),蔬菜为RR为0.94(95% CI 0.89–0.98, I2=48%, n=20, N=12563),水果RR为0.92 (95% CI 0.89–0.95, I2=57%, n=23, N=14506)。该研究结果在不同类型的蔬菜和水果中具有一致性。相关程度因地域不同而不同。水果和蔬菜摄入与肺癌风险的非线性相关表明,如果每天进食400g以上的水果和蔬菜,将没有进一步的获益。

以上研究结果显示,消除烟草是预防肺癌的最好的方法。摄吸烟的残留混合因素虽然不能被排除,但就目前研究显示摄入更多水果和蔬菜可以降低8-18%的肺癌风险。

原始出处

Vieira AR1, Abar L2, Vingeliene S2, Chan DS2, Aune D3, Navarro-Rosenblatt D2, Stevens C2, Greenwood D4, Norat T2.Fruits, vegetables and lung cancer risk: a systematic review and meta-analysis.Ann Oncol. 2015 Sep 14.

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    2016-06-13 minlingfeng
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    2015-10-23 m510429

    多吃哪些水果和蔬菜呢?

    0

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    2015-10-23 lixh1719

    多吃水果和蔬菜远离任何疾病

    0

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    2015-10-23 Guoxj3234

    多吃素,多运动

    0

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    2015-10-23 Wei Junhui

    0

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    2015-10-23 Wei Junhui

    0

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    2015-10-23 Wei Junhui

    0

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    2015-10-23 Wei Junhui

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