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Stroke:循环中性激素结合球蛋白与缺血性卒中风险

2020-02-14 xing.T MedSci原创

在这个绝经后妇女的前瞻性队列中,血清SHBG水平与IS风险之间存在显著的负相关,这些结果支持SHBG可以用作预测妇女IS危险分层工具的观点。

循环中性激素结合球蛋白(SHBG)的水平与肥胖症、糖尿病和其他心脏代谢疾病呈负相关。尚不明确低SHBG是否可预测卒中风险,特别是女性。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员调查了妇女健康倡议(WHI)项目中女性的SHBG是否与缺血性卒中(IS)风险有关。

1993年至1998年,研究人员对美国40个地区参加WHI的161808名绝经后妇女进行了观察性队列,确定了13192名基线时无卒中的参与者,这些参与者测量了血清SHBG水平。研究人员使用Cox比例风险回归(通过SHBG测量分析进行分层)评估了SHBG(Q1-Q5)五分位数水平的IS风险,首先针对人口统计学变量(模型1)进行了调整,此外还针对体重指数、高血压、饮酒和吸烟状态(模型2),以及体育活动和生殖危险因素(模型3)进行了调整。在敏感性分析中,包括潜在的介导因素(糖尿病状态、雌二醇、睾丸激素和CRP[C反应蛋白]水平)。

在平均随访11.6年之后,对13192名参与者(平均年龄为62.5岁;非西班牙裔白人占67.4%,非西班牙裔白人占18.5%,西班牙裔占7.6%和亚洲裔占5.0%)进行了裁决,共判定了768件IS事件。与SHBG水平的最高五分位数相比(参考),在所有3个多变量模型中,处于最低SHBG五分位数的女性具有较高的IS风险(模型1:风险比为1.88[95%CI为1.47-2.41];模型2:风险比为1.69[95%CI为1.30-2.20];模型3:风险比为1.61[95%CI为1.19-2.19];趋势检验所有模型的P<0.05)。在包括糖尿病、雌二醇和睾丸激素等潜在介导因素的模型中关联有所减弱但并未消除SHBG与IS之间的显著的负相关。

在这个绝经后妇女的前瞻性队列中,血清SHBG水平与IS风险之间存在显著的负相关,这些结果支持SHBG可以用作预测妇女IS危险分层工具的观点。

原始出处:

Tracy E. Madsen.et al.Circulating SHBG (Sex Hormone-Binding Globulin) and Risk of Ischemic Stroke Findings From the WHI.stroke.2020.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.028905

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    2020-03-02 xzw113
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    2020-02-14 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1893262, encodeId=d6651893262dd, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Wed Dec 02 07:36:00 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1653897, encodeId=ee48165389eb1, content=<a href='/topic/show?id=d71952689d7' target=_blank style='color:#2F92EE;'>#性激素结合球蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52689, encryptionId=d71952689d7, topicName=性激素结合球蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8be624396806, createdName=海豹, createdTime=Tue Dec 22 19:36:00 CST 2020, time=2020-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035212, encodeId=dcd720352121e, content=<a href='/topic/show?id=5a426866eae' target=_blank style='color:#2F92EE;'>#球蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68667, encryptionId=5a426866eae, topicName=球蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Mon Mar 02 17:36:00 CST 2020, time=2020-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806375, encodeId=bf2a18063e508, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Wed May 27 13:36:00 CST 2020, time=2020-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281337, encodeId=0e08128133e93, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Sun Feb 16 03:36:00 CST 2020, time=2020-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1286399, encodeId=79f1128639942, content=<a href='/topic/show?id=24395268347' target=_blank style='color:#2F92EE;'>#性激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52683, encryptionId=24395268347, topicName=性激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=267e204, createdName=wangyang7958, createdTime=Sun Feb 16 03:36:00 CST 2020, time=2020-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026559, encodeId=03271026559cd, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Feb 14 15:36:00 CST 2020, time=2020-02-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045935, encodeId=dc7e1045935f6, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Fri Feb 14 15:36:00 CST 2020, time=2020-02-14, status=1, ipAttribution=)]
    2020-02-14 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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