多喝咖啡可降低肝硬化风险，多项证据证实

2016-02-03 Mechront 译 MedSci原创

英国南安普敦大学的研究者对来自六个国家、近一百万男女的九项研究数据进行了荟萃分析，探究咖啡摄入量和肝硬化风险的关系。肝硬化常见于长期饮酒或肝炎病毒感染的患者，该疾病可导致肝衰竭和肝癌的发生，是严重威胁生命健康的疾病，也是全球性公共健康问题。因为很多未经诊断的患者的存在，导致现有的官方数据远低于实际情况。最新估计0.27%的美国人也就是633323名患有肝硬化，而其中69%的患者不知道自己有该疾病！

英国南安普敦大学的研究者对来自六个国家、近一百万男女的九项研究数据进行了荟萃分析，探究咖啡摄入量和肝硬化风险的关系。

肝硬化常见于长期饮酒或肝炎病毒感染的患者，该疾病可导致肝衰竭和肝癌的发生，是严重威胁生命健康的疾病，也是全球性公共健康问题。因为很多未经诊断的患者的存在，导致现有的官方数据远低于实际情况。最新估计0.27%的美国人也就是633323名患有肝硬化，而其中69%的患者不知道自己有该疾病！

此项荟萃分析结果显示，增加咖啡摄入量可降低肝硬化风险；剂量关系显示，咖啡摄入越多，肝硬化风险下降越厉害；每天喝2杯咖啡，可降低44%的肝硬化发生风险，降低50%的因肝硬化死亡风险！

除了咖啡因，咖啡里还含有很多生物活性成分，比如先前的研究表明，增加咖啡摄入量可降低2型糖尿病风险。

需要指出的是，该研究中增加咖啡摄入量，降低的肝硬化风险是非常大的，超过许多药物的预防作用，比如他汀类药物只能降低25%的心血管疾病风险；此外相对于药物，咖啡还有耐受性好、安全等优点。

最后作者总结道：“该研究结果指出，肝硬化高危人群服用咖啡，可显著降低风险，改善健康结局。不过对咖啡的研究还需要深入了解广泛存在的优劣性！因此医生建议此类患者多饮咖啡时，也应该做特殊说明。”

另外，MedSci编辑还检索了去年一篇类信研究，荟萃了16个研究，共132076位不喝咖啡和3034位喝咖啡的人群进行对比，发现与不喝咖啡的人群相比，肝硬化风险下降39% （OR:0.61，95%CI: 0.45-0.84），而且呈剂量依赖性。另外，亚组分析发现，在合并丙肝肝硬化的人群中，同样适用。这里两篇结果都印证了同一个事实：咖啡能减少肝硬化风险。

亲们，接下来，你准备怎么做？

原始出处：

Kennedy OJ, Roderick P, Buchanan R, Fallowfield JA, Hayes PC, Parkes J. Systematic review with meta-analysis: coffee consumption and the risk of cirrhosis,Alimentary Pharmacology & Therapeutics, doi:10.1097/MCG.0000000000000208, published online 25 January 2016.

Liu F, Wang X, Wu G, Chen L, Hu P, Ren H, Hu H.Coffee Consumption Decreases Risks for Hepatic Fibrosis and Cirrhosis: A Meta-Analysis. PLoS One. 2015 Nov 10;10(11):e0142457

Bambha K, Wilson LA, Unalp A, Loomba R, Neuschwander-Tetri BA, Brunt EM, Bass NM; Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN).Coffee consumption in NAFLD patients with lower insulin resistance is associated with lower risk of severe fibrosis. Liver Int. 2014 Sep;34(8):1250-8.

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2016-04-10 忠诚向上

值得学习

135 0
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2016-04-10 忠诚向上

值得学习

175 0
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2016-04-10 忠诚向上

值得学习

145 0
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2016-04-10 忠诚向上

值得学习

150 0
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2016-04-10 忠诚向上

值得学习

115 0
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2016-04-10 忠诚向上

值得学习

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