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Nat Med:治疗慢性病毒感染有新招

2015-03-26 佚名 生物谷

近日,来自美国的科学家在著名国际期刊nature medicine在线发表了他们的最新研究进展,他们发现慢性病毒感染如HIV等会导致细胞毒性T淋巴细胞功能衰退,在这个过程中前列腺素E2(PGE2)相关信号通路发挥了重要促进作用,因此,抑制PEG2或是治疗慢性病毒感染的一种有效手段。 目前,世界上有超过10%的人口正遭受HIV,HCV和HBV等慢性病毒感染的折磨,这几种疾病均可能引发严重并发症甚至死

近日,来自美国的科学家在著名国际期刊nature medicine在线发表了他们的最新研究进展,他们发现慢性病毒感染如HIV等会导致细胞毒性T淋巴细胞功能衰退,在这个过程中前列腺素E2(PGE2)相关信号通路发挥了重要促进作用,因此,抑制PEG2或是治疗慢性病毒感染的一种有效手段。

目前,世界上有超过10%的人口正遭受HIV,HCV和HBV等慢性病毒感染的折磨,这几种疾病均可能引发严重并发症甚至死亡。持续的抗原刺激会引起病毒特异性的细胞毒性T淋巴细胞(CTL)发生功能衰退,细胞死亡,导致HIV,HCV和HBV等病毒持续存在。除此之外,抗病毒性CTL会通过上调抑制性受体,如PD-1,自发性抑制它们对免疫病原体的限制作用。发现并阻断这些诱导CTL紊乱的信号途径可能有助于清除慢性病毒感染。

研究人员发现在慢性淋巴细胞性脉络丛脑膜炎病毒(LCMV)感染过程中前列腺素E2(PGE2)受体EP2和EP4在病毒特异性CTL中会发生上调,抑制CTL存活和正常功能发挥。他们证明联合阻断PGE2和PD-1信号途径在改善病毒控制,扩增具有正常功能的病毒特异性CTL细胞方面具有很好的效果。

综上所述,该项研究证明抑制PEG2既是一种靶向治疗慢性病毒感染的独立治疗手段,又能够与阻断PD-1信号联合作用治疗慢性病毒感染,具有重要应用前景。


原始出处:

Jonathan H Chen,Curtis J Perry, Yao-Chen Tsui,Matthew M Staron, Ian A Parish,Claudia X Dominguez,Daniel W Rosenberg& Susan M Kaech.Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection[J].Nature Medicine (2015) doi:10.1038/nm.3831.

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    2016-01-16 liye789132251
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    2015-03-28 qjddjq
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