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Am J Gastroenterology:血小板计数不能预测肝硬化患者的出血

2018-04-07 MedSci MedSci原创

血小板减少症是肝硬化患者的一个标志,它被认为是出血事件的危险因素。然而,血小板计数与出血的关系仍不清楚。

目的与背景:

血小板减少症是肝硬化患者的一个标志,它被认为是出血事件的危险因素。然而,血小板计数与出血的关系仍不清楚。

方法:

研究人员在大约 4年的随访期间调查了血小板计数与主要或临床相关的非主要出血之间的关系。

结果:

共有280例不同程度肝脏疾病的肝硬化患者(67%为男性; 64±37岁;)随访平均值为1,129(四分位间距:800-1,498)天953.12病人年的观察。年出血率为5.45%/年(分别为3.57%/年和1.89%/年)。五十二名(18.6%)患者经历了重大(N= 34)或次要(N= 18)出血事件,主要来自胃肠。血小板计数随着肝脏疾病的恶化而逐渐下降,在伴或不伴大出血或轻微出血的患者中血小板计数相似:血小板计数≤50×10 3/μl在3例(6%)患者中和20例(9%)患者中未检测到任何出血事件。相反,凝血酶原时间 国际标准化比率略高于全身或大出血患者。在Cox比例风险分析中,只有以前的消化道出血(危险比(HR):1.96; 95%置信区间:1.11-3.47; P = 0.020)和脑病(HR:2.05; 95%置信区间:1.16-3.62; P = 0.013)独立预测总体出血事件。

结论:

血小板计数并不能预测肝硬化患者的无意识大出血或轻微出血。

原始出处:
S Basili. Et al. Platelet Count Does Not Predict Bleeding in Cirrhotic Patients: Results from the PRO-LIVER Study. Am J Gastroenterology. 2018.

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