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Br J Anaesth:术中少尿可预测腹部手术后急性肾损伤的发生

2017-12-06 王贵龙 “罂粟花”微信号

术中尿量阈值与急性肾损伤(AKI)的发生风险增加尚不清楚。本研究主要探讨腹部大手术患者术中尿量与术后AKI之间的关系,从而明确AKI发生风险增加时的尿量阈值。

背景与目的:术中尿量阈值与急性肾损伤(AKI)的发生风险增加尚不清楚。本研究主要探讨腹部大手术患者术中尿量与术后AKI之间的关系,从而明确AKI发生风险增加时的尿量阈值。

方  法:对在日本京都大学附属医院接受腹部手术(肝,结直肠,胃,胰或食管切除)的3560例患者的围手术期资料进行回顾性分析。本研究评估了术中尿量和术后AKI的发生之间的关系。进行Logistic回归分析以分析相关变量,并使用P值法,最终确定从AKI发生风险增加时尿量的阈值。

结  果:本研究中AKI发生率为6.3%;使用最小P值法,可确定尿量最小阈值为0.3 ml∕kg∕h,低于此阈值AKI发生风险增加(校正比=2.65;95%CI:1.77~3.69;P﹤0.001);此模型与传统的AKI评分标准比较无明显差异(95%CI:0.049~0.270;P=0.05)

结  论:在接受腹部大手术的患者中,术中尿<0.3ml∕kg∕h 时,术后AKI发生风险增加。

原始出处:

Mizota T,et al.,Intraoperative oliguria predicts acute kidney injury after major abdominal surgery.Br J Anaesth. 2017 Dec 1;119(6):1127-1134.

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