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J INTERN MED:巨细胞动脉炎和/或风湿性多肌痛患者的血栓栓塞风险如何?

2022-01-05 MedSci原创 MedSci原创

GCA、PMR和两种疾病合并的患者发生血栓栓塞事件风险各补相同。研究人员发现可能有助于根据疾病表型预测血栓栓塞事件的风险。

巨细胞动脉炎(GCA)和风湿性多肌痛(PMR)是主要影响老年妇女的全身炎症性疾病。

近日,内科学领域权威杂志Journal of Internal Medicine上发表一篇研究文章,该研究旨在比较伴有GCA和/或PMR的骨关节炎(OA)患者血栓栓塞事件和视网膜血管阻塞的风险。

在这项回顾性研究中,共有1535名GCA患者、10265名PMR患者和1203名两种疾病合并的患者,以及39009名年龄和性别匹配的OA患者。随着时间的推移,研究人员计算并评估了肺栓塞(PE)、深静脉血栓形成(DVT)、动脉血栓栓塞(ATE)、视网膜中央动脉阻塞(CRAO)和视网膜中央静脉阻塞(CRVO)的发生率比(IRR)。研究人员绘制了累积发生率并计算血栓栓塞事件的风险比,并调整了血栓栓塞的独立危险因素。

与OA患者相比,GCA和两种疾病合并的患者发生所有血栓栓塞事件具有更高的IRR。与两种疾病合并的患者(分别有HR为2.01,95%CI为1.35-2.99,p<0.001;HR为2.37,95%CI为1.23-4.53,p=0.009)或单独PMR的患者(分别有HR为1.89,95%CI为1.50-2.41,p<0.001;HR为4.68,95%CI为3.10-7.07,p<0.001,分别)相比,GCA患者发生DVT和视网膜血管阻塞的风险更高。GCA患者发生PE的风险高于PMR患者(HR为1.55,95%CI为1.1-2.18,p=0.01)。

由此可见,GCA、PMR和两种疾病合并的患者发生血栓栓塞事件风险各补相同。研究人员发现可能有助于根据疾病表型预测血栓栓塞事件的风险。

原始出处:

Despina Michailidou,et al.Risk of venous and arterial thromboembolism in patients with giant cell arteritis and/or polymyalgia rheumatica: A Veterans Health Administration population-based study in the United States.Journal of Internal Medicine.2022.https://onlinelibrary.wiley.com/doi/10.1111/joim.13446

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    2022-05-13 xsm927
  2. [GetPortalCommentsPageByObjectIdResponse(id=1683227, encodeId=dc26168322eb5, content=<a href='/topic/show?id=60f03325e28' target=_blank style='color:#2F92EE;'>#动脉炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33257, encryptionId=60f03325e28, topicName=动脉炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d22a27947071, createdName=xsm927, createdTime=Fri May 13 10:58:47 CST 2022, time=2022-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1184453, encodeId=6202118445311, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58001397990, createdName=yx1156, createdTime=Sat Jan 15 05:17:04 CST 2022, time=2022-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502299, encodeId=9c01150229900, content=<a href='/topic/show?id=021d4821096' target=_blank style='color:#2F92EE;'>#巨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48210, encryptionId=021d4821096, topicName=巨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11759518880, createdName=wwzzly, createdTime=Fri Jan 07 09:58:47 CST 2022, time=2022-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611401, encodeId=49dc161140144, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Jan 07 09:58:47 CST 2022, time=2022-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1181214, encodeId=c3ce118121454, content=累计死亡病例548.1万例,达到, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Thu Jan 06 09:51:46 CST 2022, time=2022-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1181130, encodeId=9dc6118113061, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Thu Jan 06 06:14:30 CST 2022, time=2022-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1181041, encodeId=74251181041ad, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0add6441252, createdName=刀客特张, createdTime=Wed Jan 05 21:06:11 CST 2022, time=2022-01-05, status=1, ipAttribution=)]
    2022-01-15 yx1156

    好文章!

    0

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    2022-01-07 wwzzly
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    2022-01-06 查查佳佳

    累计死亡病例548.1万例,达到

    0

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    2022-01-06 学医无涯

    学习一下

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    2022-01-05 刀客特张

    学习

    0

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