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Eur Radiol:急性下消化道出血患者的福音!

2021-03-16 shaosai MedSci原创

急性下消化道出血(LGIB)是指从消化道远端至Treitz韧带的消化道内出血。大约50%的急性LGIB不需要侵入式诊断或干预就会自行停止。

    急性下消化道出血(LGIB)是指从消化道远端至Treitz韧带的消化道内出血。大约50%的急性LGIB不需要侵入式诊断或干预就会自行停止。然而那仍有大部分急性LGIB患者由于出血不能自发停止而需要接受适当的血流动力学复苏和紧急干预以控制出血,因此,对这部分高风险患者的早期识别对临床治疗至关重要。

    对于持续GIB和血流动力学不稳定的高危患者,尤其是结肠镜止血失败和小肠出血患者,经导管动脉栓塞是一线治疗方法。由于LGIB具有间歇性或渗出性的特点,数字减影血管造影(DSA)对LGIB的整体敏感性较低,仅为37 - 62%,若DSA中未能发现出血部位则将阻碍进一步的栓塞治疗。

    现阶段,计算机断层血管造影(CTA)已被用作LGIB的一线检查方式。首先,CTA在检测对比剂外溢和定位出血部位方面具有较高的敏感性(90%)。其次,CTA阴性是出血停止的良好指证,从而避免进行不必要的血管造影检查。第三,CTA阳性是紧急DSA的可靠指征。

考虑到CTA的作用和敏感性,一种经验性锥形束CT (CBCT)引导的LGIB栓塞技术已引入临床的实际操作中。CBCT已集成到平板血管造影套件中,可以在导管插入过程中提供立体解剖学信息。当将动脉内CBCT与阳性CTA进行解剖比较时,即使在没有对比剂外渗的情况下,出血部位也可以与超选择性导管相匹配。


    近日,发表在European Radiology杂志的一项研究评估了在CTA阳性且DSA阴性的急性LGIB患者中行CBCT引导下经验性栓塞治疗的总体可行性、安全性及可能产生副作用,为CBCT在临床的进一步应用提供了理论支持及技术指导。

    本研究回顾性研究了自2008年1月至2019年7月CTA阳性且24小时内接受DSA检查的连续LGIB患者。DSA阳性的患者接受了靶向栓塞治疗(TE组)。DSA阴性的患者接受经验性CBCT介导的假设管腔破裂栓塞术(EE组)或未栓塞术(NE组)。采用Fisher精确检验比较了复发性出血、主要缺血性并发症和院内死亡率。根据血液动力学的不稳定性进行了进一步的亚组分析。

    本研究共纳入85例患者(67.6岁±15.7,52名男性)(TE组,n = 47; EE组,n = 19; NE组,n = 19)。如果DSA呈阳性,则靶向栓塞术的技术成功率为100%(47/47)。如果DSA阴性并且通过经验性CBCT引导栓塞治疗,则技术成功率为100%(19/19)。TE组、EE组和NE组的复发出血率分别为17.0%(8/47)、21.1%(4/19)和52.6%(10/19)。 DSA阴性和血流动力学不稳定的患者,经验性CBCT引导的栓塞术可显著减少再出血的发生(EE组,3/10 vs NE组,10/12,p = .027)。一名患者(TE组)发生了严重的缺血性并发症。 总体而言,院内死亡率为7.1%(6/85)。

 表 各组患者的临床预后

    对于CTA阳性、DSA阴性且血流动力学不稳定的急性LGIB患者来说,经验性锥形束CT (CBCT)引导的栓塞技术是一种可行、有效且安全的治疗策略,同时可以减少再出血的发生率并提高临床成功率,为临床提供了早期诊断及治疗急性LGIB的新的可靠技术。


原始出处:

Laurens Hermie,Elisabeth Dhondt,Peter Vanlangenhove,et al. Empiric cone-beam CT-guided embolization in acute lower gastrointestinal bleeding.DOI:10.1007/s00330-020-07232-7

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    2021-04-29 ms6000001624652641

    急性下消化道出血任重道远

    0

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    学习了

    0

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    2021-03-16 ms4000001649866442

    学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1706049, encodeId=3d6a1e0604930, content=<a href='/topic/show?id=6fb0521e42a' target=_blank style='color:#2F92EE;'>#急性下消化道出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52174, encryptionId=6fb0521e42a, topicName=急性下消化道出血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=14f431139253, createdName=zengjiayao, createdTime=Thu Sep 30 14:06:58 CST 2021, time=2021-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961468, encodeId=f404961468de, content=急性下消化道出血任重道远, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd5b5469613, createdName=ms6000001624652641, createdTime=Thu Apr 29 10:53:11 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446548, encodeId=7ae31446548c3, content=<a href='/topic/show?id=4a672015341' target=_blank style='color:#2F92EE;'>#下消化道出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20153, encryptionId=4a672015341, topicName=下消化道出血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=65305226247, createdName=bioon3, createdTime=Thu Mar 18 08:06:58 CST 2021, time=2021-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464676, encodeId=4a8014646e6d2, content=<a href='/topic/show?id=32e765e6591' target=_blank style='color:#2F92EE;'>#消化道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65765, encryptionId=32e765e6591, topicName=消化道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7b6e6676048, createdName=changhe715, createdTime=Thu Mar 18 08:06:58 CST 2021, time=2021-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948805, encodeId=8a1a94880502, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210316/a583325910c445c5a9c4f1f0fbc42428/a82cd787a52042539283fb2f2c1fad3b.jpg, createdBy=025c5115557, createdName=14624b5bm99暂无昵称, createdTime=Tue Mar 16 20:40:16 CST 2021, time=2021-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948804, encodeId=4089948804a4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210316/a583325910c445c5a9c4f1f0fbc42428/a82cd787a52042539283fb2f2c1fad3b.jpg, createdBy=025c5115557, createdName=14624b5bm99暂无昵称, createdTime=Tue Mar 16 20:39:49 CST 2021, time=2021-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948789, encodeId=3c13948e89b7, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210314/e42046bcb2c34001a84c9ce87c646b61/3e25c3faf3f44523810c81494127b634.jpg, createdBy=6cec5468406, createdName=ms4000001649866442, createdTime=Tue Mar 16 19:38:45 CST 2021, time=2021-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948744, encodeId=d3db948e441b, content=🐂, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99d51664860, createdName=1ddf9888m63(暂无匿称), createdTime=Tue Mar 16 17:25:32 CST 2021, time=2021-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=948742, encodeId=b9ab948e4270, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Tue Mar 16 17:19:35 CST 2021, time=2021-03-16, status=1, ipAttribution=)]
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    2021-03-16 医鸣惊人

    认真学习了

    0

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