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Nature Microbiology:欣喜!广谱埃博拉病毒疫苗新突破

2018-05-10 小通 生物通

Nature Microbiology》发文,联合课题组成功研制出新型埃博拉抗体,这种抗体可用于多种埃博拉病毒治疗。


《Nature Microbiology》发文,联合课题组成功研制出新型埃博拉抗体,这种抗体可用于多种埃博拉病毒治疗。

埃博拉病毒(Ebola virus)危及全球健康,感染后死亡率很高。科学家们开发了几种策略,包括在非人类灵长类动物身上已经看到成效的ZMapp,而且已被纳入人类关怀治疗手册(compassionate-treatment protocols)使用范围。

“ZMapp的问题在于,它对最近爆发的埃博拉疫情有较好的效果,但是它对其他埃博拉病毒株,包括Bundibugyo、Reston或Sudan都没有中和效果,”德州大学Galveston医学分部教授、病毒学家Alex Bukreyev说。“我们在感染Bundibugyo ebolavirus的人类幸存者体内鉴定了三种天然抗体,它们对几种不同埃博拉病毒都有中和和保护作用。”新发现的抗体与埃博拉病毒的结合位点与以往发现抗体的不同。

有关埃博拉病毒:

据疾控中心报道,埃博拉病毒的首次发现地点是刚果民主共和国埃博拉河附近(1976年),自那以后,该病毒不时感染人类,在非洲等国多次导致疫情爆发。

埃博拉病毒的常见种类:

埃博拉病毒(Ebola virus) 即扎伊尔埃博拉病毒(Zaire ebolavirus)

苏丹病毒(Sudan virus),即苏丹埃博拉病毒(Sudan ebolavirus)

塔伊森林病毒(Ta? Forest virus ),即塔伊森林埃博拉病毒,原名科特迪瓦埃博拉病毒(Ta? Forest ebolavirus, formerly C?te d'Ivoire ebolavirus)

本迪布焦病毒(Bundibugyo virus),即本迪布焦埃博拉病毒(Bundibugyo ebolavirus)

莱斯顿病毒(Reston virus ),即已知在非人灵长类动物和猪中致病,但不引起人类疾病的莱斯顿埃博拉病毒(Sudan ebolavirus)

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    2019-01-22 liye789132251
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    2019-04-01 xjy02
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1724979, encodeId=f4c71e249793d, content=<a href='/topic/show?id=9ee758586bb' target=_blank style='color:#2F92EE;'>#新突破#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58586, encryptionId=9ee758586bb, topicName=新突破)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=792a33728807, createdName=zxxiang, createdTime=Mon Jul 09 23:02:00 CST 2018, time=2018-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857645, encodeId=f8fa185e6453a, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Mar 10 08:02:00 CST 2019, time=2019-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2083299, encodeId=8bda2083299b8, content=<a href='/topic/show?id=b7cce09742a' target=_blank style='color:#2F92EE;'>#病毒疫苗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70974, encryptionId=b7cce09742a, topicName=病毒疫苗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1dbc2500219, createdName=huagfeg, createdTime=Sat Jan 26 14:02:00 CST 2019, time=2019-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1883027, encodeId=4a7d188302e18, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Jan 22 01:02:00 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084397, encodeId=e52d208439eea, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Mon Apr 01 23:02:00 CST 2019, time=2019-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1767446, encodeId=6efe1e67446a5, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Wed Jul 25 00:02:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650373, encodeId=5cd316503e3f4, content=<a href='/topic/show?id=9e424155935' target=_blank style='color:#2F92EE;'>#埃博拉病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41559, encryptionId=9e424155935, topicName=埃博拉病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=639b24003788, createdName=tcm107hq, createdTime=Sat Sep 15 05:02:00 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918083, encodeId=25e1191808385, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Jan 06 03:02:00 CST 2019, time=2019-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1296478, encodeId=50a412964e800, content=<a href='/topic/show?id=76f941560d7' target=_blank style='color:#2F92EE;'>#埃博拉病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41560, encryptionId=76f941560d7, topicName=埃博拉病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Sat May 12 14:02:00 CST 2018, time=2018-05-12, status=1, ipAttribution=)]
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    2019-01-06 sunylz
  9. 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