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Biomed Mater:新型生物活性玻璃纤维可有效促进成骨

2018-10-10 MedSci MedSci原创

基于玻璃纤维的材料在生物医学和牙科的应用引起了研究人员的极大兴趣。本研究旨在通过使用微波辐射技术的新方法使E-玻璃纤维具有生物活性。 使用水解方法表面活化后使用工业E-玻璃纤维。钙和磷前体的比例设定为1.67。在保持钙溶液的pH后,加入两种比例的E-玻璃纤维,即30%(nHA/E30)和50%(nHA/E50)wt/wt,然后加入磷前体并在微波中照射溶液。在E-玻璃纤维上获得纳米羟基磷灰石(

基于玻璃纤维的材料在生物医学和牙科的应用引起了研究人员的极大兴趣。本研究旨在通过使用微波辐射技术的新方法使E-玻璃纤维具有生物活性。

使用水解方法表面活化后使用工业E-玻璃纤维。钙和磷前体的比例设定为1.67。在保持钙溶液的pH后,加入两种比例的E-玻璃纤维,即30%(nHA/E30)和50%(nHA/E50)wt/wt,然后加入磷前体并在微波中照射溶液。在E-玻璃纤维上获得纳米羟基磷灰石(nHA)颗粒。对所得材料进行结构,物理和体外生物相容性分析。通过逆转录聚合酶链式反应(RT-PCR)测量骨桥蛋白(OPN)和1型胶原(Col)1的表达,并在所有组之间进行比较。

傅立叶变换红外光谱和X射线衍射显示出nHA的特征峰,并且随着E-玻璃纤维浓度的增加观察到峰强度的变化。扫描电子显微镜(SEM)图像证实了nHA球形颗粒在整个纤维上的均匀粘附。间充质干细胞的细胞活力、增殖和粘附增加。所有材料都能够上调OPN和Col的表达,其中基因表达在nHA中最高,接着是nHA/E30和nHA/E50。

综上所述,该研究结果表明,生物活性玻璃纤维在最短时间内合成,并显示出成骨性能。这些材料有可能用于骨组织工程,牙科修复和牙齿修复。

原始出处:

Khalid H, Suhaib F, et al., Microwave-assisted synthesis and in vitro osteogenic analysis of novel bioactive glass fibers for biomedical and dental applications. Biomed Mater. 2018 Sep 25. doi: 10.1088/1748-605X/aae3f0.

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    2019-05-28 sunylz
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    2018-10-12 zhaojie88
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