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JAHA:疑似冠状动脉疾病患者心外膜脂肪量与阻塞性冠状动脉疾病风险相关

2021-03-04 MedSci原创 MedSci原创

在中国疑似CAD的患者中,EFV与阻塞性CAD的风险之间存在显著正相关,而与传统危险因素和冠状动脉钙化之间无关。

心外膜脂肪组织可能与冠状动脉疾病(CAD)的发病机理有关,但其对阻塞性CAD风险的影响尚未明确。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在探究中国疑似CAD患者心外膜脂肪组织与阻塞性CAD之间的关系。

该研究招募了194例连续就诊的接受非造影计算机断层扫描和冠状动脉造影检查的疑似CAD患者。研究人员测量了心外膜脂肪量(EFV),并评估了其与阻塞性CAD之间的关系。阻塞性CAD被定义为冠状动脉狭窄严重程度≥70%。

总体而言,44.3%受试者患有阻塞性CAD,并倾向具有较高的EFV。随着EFV三分位数的增加,受试者年龄、体重指数、甘油三酯、高血压发生率和高脂血症发生率更高(趋势P<0.05)。在单变量回归分析中,EFV的每增加1个SD与阻塞性CAD之间独立相关(比值比[OR]为2.31;95%CI为1.61-3.32;P<0.001)。与这些结果一致的是,在校正所有传统危险因素和冠状动脉钙后,EFV仍与阻塞性CAD显著相关(增加1个SD的OR为2.82;95%CI为1.64-4.74;P<0.001)。广义添加模型表明EFV与阻塞性CAD的风险之间呈线性关系。

该研究的结果表明,在中国疑似CAD的患者中,EFV与阻塞性CAD的风险之间存在显著正相关,而与传统危险因素和冠状动脉钙化之间无关

原始出处:

Wenji Yu.et al.Association of Epicardial Fat Volume With Increased Risk of Obstructive Coronary Artery Disease in Chinese Patients With Suspected Coronary Artery Disease.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/10.1161/JAHA.120.018080

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    2021-09-08 tomyang96
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    2021-03-10 苏小雨

    学习了,非常好

    0

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    2021-03-06 zhaohui6731
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    2021-03-04 飞翔的乌龟

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