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Infect Dis：摩洛哥两例婴儿内脏和局部皮肤利什曼病案例报道

2018-04-25 MedSci MedSci原创

皮肤利什曼病
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利什曼病是一种由原生动物利什曼原虫引起的媒传疾病。这些疾病的临床表现包括良性皮肤病变到内脏型。在地中海地区，人畜共患内脏利什曼病(ZVL)是由L. infantum引起的。如果两年内未得到治疗，这种疾病通常会导致死亡。在摩洛哥，ZVL是北方地区的地方病，每年有100个病例，其中大部分是5岁以下的儿童。在这里，我们报道了摩洛哥2名婴儿的临床观察研究，他们表现出不同寻常的伴随性利什曼病和皮肤利什曼病(

利什曼病是一种由原生动物利什曼原虫引起的媒传疾病。这些疾病的临床表现包括良性皮肤病变到内脏型。在地中海地区，人畜共患内脏利什曼病(ZVL)是由L. infantum引起的。如果两年内未得到治疗，这种疾病通常会导致死亡。在摩洛哥，ZVL是北方地区的地方病，每年有100个病例，其中大部分是5岁以下的儿童。在这里，我们报道了摩洛哥2名婴儿的临床观察研究，他们表现出不同寻常的伴随性利什曼病和皮肤利什曼病(CL)。 在本案例中，我们报告了两例分别为9岁和12个月大的婴儿。他们的病史均包括发热性脾肿大、贫血和粘膜发白。经寄生虫学诊断证实为内脏利什曼病(阳性骨髓涂片和抗L. infantum抗体筛选)。然而，临床检查也显示皮肤病变，提示存在CL。由于病人有流行区生活或旅行史而进一步加剧病情。因此，对患者皮肤分泌物进行直接检查、培养和PCR-RFLP (1- haeiii)检测。其中一个婴儿，CL与L. infantum有关，而在另一个婴儿中，它与L. tropica有关。，这些婴儿根据卫生部的建议进行治疗。两名婴儿患者均在两个月内痊愈：退热，脾肿大减少，皮肤损伤愈合。 这些罕见的婴儿患者病例报告说明

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1951234, encodeId=4b591951234a3, content=<a href='/topic/show?id=4f5c322640f' target=_blank style='color:#2F92EE;'>#利什曼病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32264, encryptionId=4f5c322640f, topicName=利什曼病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Thu Feb 07 22:00:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012651, encodeId=53162012651ca, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Aug 25 14:00:00 CST 2018, time=2018-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405830, encodeId=3636140583029, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Fri Apr 27 11:00:00 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2019-02-07 jiangfeng5067

    #利什曼病#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1951234, encodeId=4b591951234a3, content=<a href='/topic/show?id=4f5c322640f' target=_blank style='color:#2F92EE;'>#利什曼病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32264, encryptionId=4f5c322640f, topicName=利什曼病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Thu Feb 07 22:00:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012651, encodeId=53162012651ca, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Aug 25 14:00:00 CST 2018, time=2018-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405830, encodeId=3636140583029, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Fri Apr 27 11:00:00 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2018-08-25 cmj8wellington

    #Dis#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1951234, encodeId=4b591951234a3, content=<a href='/topic/show?id=4f5c322640f' target=_blank style='color:#2F92EE;'>#利什曼病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32264, encryptionId=4f5c322640f, topicName=利什曼病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e0a1165, createdName=jiangfeng5067, createdTime=Thu Feb 07 22:00:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012651, encodeId=53162012651ca, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Aug 25 14:00:00 CST 2018, time=2018-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405830, encodeId=3636140583029, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Fri Apr 27 11:00:00 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
    2018-04-27 chg122

    #局部#

    0

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