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总胆固醇、甘油三酯、LDL-C...血脂报告全面解读!

2022-01-28 综合整理 综合整理

血脂报告单中最重要的四个数值——血脂四项,它的来源以及意义是什么,一起来学学吧。

随着经济的发展和人们健康意识的提高,血脂检查已经是大部分体检的必备项目,据统计中国成人血脂异常达到40.4%,控制好血脂水平对于预防心脑血管疾病至关重要。今天这里就向大家介绍一下,血脂报告单中最重要的四个数值——血脂四项,它的来源以及意义是什么,一起来学学吧。

 血脂四项包括:

  • 甘油三酯(TG)

  • 胆固醇(TC)

  • 低密度脂蛋白胆固醇(LDL)

  • 高密度脂蛋白胆固醇(HDL)

图片

什么是血脂

血脂是血浆中脂类物质的总称。脂类物质分为脂肪和类脂,其中脂肪又称有甘油三酯,功能是供应能量和储存能量;类脂包括胆固醇、磷脂、类固醇和糖脂等,功能是维持生物膜的正常结构和功能。

总胆固醇(TC)

血液中所有脂蛋白所含胆固醇的总和,分内源性和外源性。内源性TC由机体自身合成,约50%以上的TC来自机体合成;外源性TC主要来自动物的内脏、蛋黄、奶油及肉等动物性食品。因此,TC受食物的即刻影响较小,是血脂升高的“主犯”。

参考范围:0.0——5.2mmol/L

边缘升高:≥5.2mmol/L且<6.2mmol/L

升高:≥6.2mmol/L

影响TC水平的主要因素有:

①年龄与性别:TC水平常随年龄而上升,但70岁后不再上升甚或有所下降,中青年女性低于男性,女性绝经后TC水平较同年龄男性高。

②饮食习惯:长期高胆固醇、高饱和脂肪酸摄入可使TC 升高。

③遗传因素:酶或基因受体基因突变,如家族性遗传性高胆固醇血症,是引起TC显著升高的主要原因。

④缺乏运动:TC升高常见于动脉粥样硬化、原发性高血脂、糖尿病等。

降低见于恶性贫血、溶血性贫血、甲状腺机能亢进、急性感染,营养不良等。

甘油三酯(TG)

TG主要参与人体内能量代谢,产生热能。血中TG含量过高可导致血液黏稠,使脂质在血管壁上沉积,渐渐形成小斑块,即我们平常所说的动脉粥样硬化。TG的主要来源不是肉,而是主食、甜品。通常,对于仅TG高而TC正常的患者,通过调整饮食结构,TG就可能迅速降下来,是血脂升高的“从犯”。

参考范围:0.0——1.7mmol/L

边缘升高:≥1.7mmol/L且<2.3mmol/L

升高:≥2.3mmol/L

同一个体TG水平受饮食和不同时间等因素的影响较大,所以同一个体在多次测定时,TG值可能有较大差异。临床上一般要求空腹测量。TG升高可见于家族遗传性、动脉粥样硬化、冠心病、糖尿病、肾病综合征、胆道梗阻、甲状腺功能减退、急性胰腺炎、糖原累积症、原发性甘油三酯增多症、酗酒;下降一般见于肝性疾病、甲亢等。

低密度脂蛋白(LDL)

参考范围:0——3.4mmol/l

理想水平:<2.6mmol/L

边缘升高:≥3.4mmol/L且<4.1mmol/L

升高:≥4.1mmol/L

影响TC的因素均可同样影响LDL水平。LDL增高是动脉粥样硬化发生、发展的主要、独立危险因素。LDL通过血管内皮进入血管壁内,在内皮下层滞留的LDL被修饰成氧化型LDL(ox-LDL),巨噬细胞吞噬ox-LDL后形成泡沫细胞,后者不断增多、融合,构成动脉粥样硬化斑块的脂质核心。大量研究表明,动脉粥样硬化是一种慢性炎症反应疾病,LDL很可能是这种慢性炎症反应的始动和维持的基本要素。一般情况下,LDL与TC是相平行,但TC水平也受HDL水平影响,故最好用LDL值取代TC,来评估动脉粥样硬化心血管疾病风险。

另外,冠心病患者根据危险分层,降脂目标不同

  • 极高危患者:LDL<1.4mmol/L(55mg/dl)且降幅>50%;

  • 高危患者:LDL<1.8mmol/L(70mg/dl)且降幅>50%

  • 中危患者:LDL<2.6mmol/L(100mg/dl)

  • 低危患者:LDL<3.0mmol/L(115mg/dl)


图片

高密度脂蛋白(HDL)

参考范围:1.16——2.42mmol/L

降低:<1.0mmol/L

由于HDL能将血管壁内胆固醇转运至肝脏进行分解代谢(即胆固醇逆转运),可减少胆固醇在血管壁的沉积,起到抗动脉粥样硬化作用,因此被称为“好”胆固醇。一般认为,HDL与心血管疾病的发病率和病变程度呈负相关。但需要注意的是,高水平的HDL,并非所有情况都一定有益。

HDL的水平明显受遗传因素影响,HDL降低常见于严重营养不良、肝炎、贫血和肝硬化等,而运动和少量饮酒会升高HDL-C。

高血脂的治疗

对于高脂血症患者,饮食治疗和生活方式改善是治疗高脂血症的基础措施。无论是否进行药物治疗,都必须坚持控制饮食和改善生活方式。良好的生活方式包括坚持心脏健康饮食、规律运动、远离烟草和保持理想体重。对于单纯改善生活方式仍无法控制血脂时,应及时给予他汀药物治疗。对于已经发展成为冠心病时,应同时给予抗血小板和抗心肌缺血治疗等。

参考文献
1. 中国成人血脂异常防治指南修订联合委员会.中国成人血脂异常防治指南(2016 年修订版).中国循环杂志.10(31):937-953.
2.葛均波,徐永健.内科学(第8版).2015;人民卫生出版社.
3.王长谦,顾俊.你知道 血脂四项的秘密吗.家庭医学,2017;1:4-7.

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    2022-11-02 ms6000002138303137

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    2022-04-13 美人骨ice

    清晰

    0

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    2022-01-31 ms3000001362015616

    学习了

    0

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    2022-01-31 red咩

    实用性强,学习了

    0

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    2022-01-30 zhwj
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    2022-01-30 290318491

    学习学习,很全面

    0

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    2022-01-29 ms6000000315019678

    学习了

    0

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    2022-01-29 moon-386

    学习了

    0

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    2022-01-29 ms1000001042400220

    学到了

    0

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