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Stroke:肥厚型心肌病患者根据房颤有无患缺血性卒中的情况

2021-10-06 MedSci原创 MedSci原创

HCM患者AF患病率高,IS风险明显,HCM患者伴有AF与较差的结局独立相关。一个简单的法国HCM评分显示了HCM患者中IS的良好预测和临床有用性,具有良好的校准。

肥厚型心肌病(HCM)患者发生缺血性卒中(IS)的风险很高,尤其是存在心房颤动(AF)的情况下。无论是否存在AF,都需要改进风险分层,以帮助识别卒中风险较高的HCM患者。

近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,这项来自涵盖2010年至2019年医院护理数据库的法国纵向队列研究分析了因孤立性HCM住院的成年人。研究人员使用Logistic回归模型构建法国HCM评分,并使用c指数和校准分析将其与HCM风险-CVA和CHA2DS2-VASc评分进行了比较。

在32206名孤立性HCM患者中,12498名(38.8%)患有AF,2489名(7.7%)患者在随访期间为持续IS。HCM患者的AF与更高的死亡风险(风险比为1.129[95%CI为1.088-1.172])、心血管死亡(风险比为1.254[95%CI为1.177-1.337])、IS(风险比为1.210[95%CI为1.111–1.317])和其他主要心血管事件相关。HCM患者中IS的独立预测因素包括年龄较大、心力衰竭、房颤、既往IS、吸烟和营养不良(所有P<0.05)。

对于HCM风险-CVA评分、CHA2DS2-VASc评分和法国HCM评分,所有c指数均为0.65至0.70,校准良好。在AF患者中,CHA2DS2-VASc评分比HCM风险-CVA评分略有改善,但与法国HCM评分相比预测性较差(P=0.001)。在没有AF的患者中,与CHA2DS2-VASc相比,HCM风险-CVA评分和法国HCM评分均具有显著更好的预测效能(均P<0.0001)。决策曲线分析表明,法国HCM评分在3个测试的风险评分中具有最佳的临床实用性。

由此可见,HCM患者AF患病率高,IS风险明显,HCM患者伴有AF与较差的结局独立相关。一个简单的法国HCM评分显示了HCM患者中IS的良好预测和临床有用性,具有良好的校准。

原始出处:

Laurent Fauchier.et al.Ischemic Stroke in Patients With Hypertrophic Cardiomyopathy According to Presence or Absence of Atrial Fibrillation.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.121.034213

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