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Stroke:隐性脑梗死亚型分类以及死亡和血管事件的风险

2019-11-26 xing.T MedSci原创

由此可见,CBI可以分为不同结局的亚型。某些CBI亚型,例如与颅内大动脉粥样硬化相关的亚型,具有较高的不良血管结局风险,因此可以考虑进行治疗试验。

近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在检验以下假设:与卒中患者相比,隐性脑梗塞(CBI)更可能位于无言语功能的脑区,并且与没有CBI的个体相比,CBI病因亚型具有不同的血管事件风险。

研究人员使用了脑磁共振对来自NOMAS(北曼哈顿研究)的1290名无卒中参与者进行影像学检查,以评估CBI,并将CBI分为:心脏栓塞(即已知的房颤)、大动脉粥样硬化(颅外和颅内)、穿透性动脉疾病和隐源性(无明显原因)。位于右半球非运动区的CBI被认为是无语言功能的。然后,研究人员使用调整后的Cox比例模型根据CBI亚型评估了事件的风险。

在磁共振成像时,236名参与者(18%)患有CBI(144名[61%]远端隐源性,29名[12%]远端心脏栓塞,26名[11%]大动脉粥样硬化和37名[16%]穿透性动脉疾病)。较小的(每毫米比值比为0.8 [0.8-0.9])和无脑梗塞(比值比为0.2 [0.1-0.6])更可能为隐源性。在随访期间(10.4±3.1年),398例(31%)患者死亡(162例[13%]血管死亡)和117例(9%)患者发生卒中,99例[85%]为缺血性卒中。发生事件的风险因CBI亚型而异,在颅内大动脉粥样硬化相关CBI参与者中发生卒中(风险比为2.2 [1.3-3.7])和血管死亡(风险比为2.24 [1.29-3.88])的风险最高。

由此可见,CBI可以分为不同结局的亚型。某些CBI亚型,例如与颅内大动脉粥样硬化相关的亚型,具有较高的不良血管结局风险,因此可以考虑进行治疗试验。 

原始出处:

Jose Gutierrez.et al.Classification of Covert Brain Infarct Subtype and Risk of Death and Vascular Events.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.026068

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1643663, encodeId=e8861643663e3, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Thu Nov 28 12:26:00 CST 2019, time=2019-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465159, encodeId=36d9146515923, content=<a href='/topic/show?id=2dea8489010' target=_blank style='color:#2F92EE;'>#脑梗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84890, encryptionId=2dea8489010, topicName=脑梗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccf56689148, createdName=karmond, createdTime=Thu Nov 28 10:26:00 CST 2019, time=2019-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375935, encodeId=a2613e5935b9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20231215/ac08b4d4cecf4bd3b9af86e00dcbca38/f6b6a60efd854ff191eb5c611ec7dd12.jpg, createdBy=8afb2071832, createdName=15938038573红旗飘飘, createdTime=Thu Nov 28 06:14:38 CST 2019, time=2019-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375882, encodeId=74203e5882b3, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Wed Nov 27 06:35:26 CST 2019, time=2019-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375876, encodeId=45563e5876cc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Nov 26 22:53:56 CST 2019, time=2019-11-26, status=1, ipAttribution=)]
    2019-11-28 karmond
  3. [GetPortalCommentsPageByObjectIdResponse(id=1643663, encodeId=e8861643663e3, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Thu Nov 28 12:26:00 CST 2019, time=2019-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465159, encodeId=36d9146515923, content=<a href='/topic/show?id=2dea8489010' target=_blank style='color:#2F92EE;'>#脑梗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84890, encryptionId=2dea8489010, topicName=脑梗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccf56689148, createdName=karmond, createdTime=Thu Nov 28 10:26:00 CST 2019, time=2019-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375935, encodeId=a2613e5935b9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20231215/ac08b4d4cecf4bd3b9af86e00dcbca38/f6b6a60efd854ff191eb5c611ec7dd12.jpg, createdBy=8afb2071832, createdName=15938038573红旗飘飘, createdTime=Thu Nov 28 06:14:38 CST 2019, time=2019-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375882, encodeId=74203e5882b3, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Wed Nov 27 06:35:26 CST 2019, time=2019-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375876, encodeId=45563e5876cc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Nov 26 22:53:56 CST 2019, time=2019-11-26, status=1, ipAttribution=)]
    2019-11-28 15938038573红旗飘飘

    学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1643663, encodeId=e8861643663e3, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Thu Nov 28 12:26:00 CST 2019, time=2019-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465159, encodeId=36d9146515923, content=<a href='/topic/show?id=2dea8489010' target=_blank style='color:#2F92EE;'>#脑梗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84890, encryptionId=2dea8489010, topicName=脑梗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccf56689148, createdName=karmond, createdTime=Thu Nov 28 10:26:00 CST 2019, time=2019-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375935, encodeId=a2613e5935b9, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20231215/ac08b4d4cecf4bd3b9af86e00dcbca38/f6b6a60efd854ff191eb5c611ec7dd12.jpg, createdBy=8afb2071832, createdName=15938038573红旗飘飘, createdTime=Thu Nov 28 06:14:38 CST 2019, time=2019-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375882, encodeId=74203e5882b3, content=谢谢了,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=30331616752, createdName=txqjm, createdTime=Wed Nov 27 06:35:26 CST 2019, time=2019-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375876, encodeId=45563e5876cc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Nov 26 22:53:56 CST 2019, time=2019-11-26, status=1, ipAttribution=)]
    2019-11-27 txqjm

    谢谢了,学习

    0

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    2019-11-26 天地飞扬

    学习了

    0

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