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J Rheumatol:患者报告的结果作为早期类风湿关节炎疾病活动变化和残疾的预测因子

2017-07-07 xiangting MedSci原创

患者报告的基线时的疲劳、疼痛和僵硬对于预测RA疾病活动(DAS28)变化和活动受限(HAQ-DI)其价值有限。

这篇文章旨在分析患者报告的可作为早期类风湿关节炎(RA)疾病活动变化和残疾预测因子的指标。

1997年至2009年期间,病例(n = 1415)纳入约克郡早期关节炎登记(YEAR)招募了。使用多层次模型确定基线和12个月28关节疾病活动评分(DAS28)和健康评估问卷-残疾指数(HAQ-DI)的预测因子。基线预测指标是性别、年龄、症状持续时间、自身抗体状态、疼痛和疲劳视觉模拟量表(VAS)、晨僵持续时间(EMS),DAS28和HAQ-DI。

女性的变化率比男性慢:男性和女性DAS28分别下降0.19和0.17单位/月,HAQ-DI分别下降0.028和0.023单位/月。基线疼痛和EMS对变化率影响不大,而疲劳VAS仅与基线时与DAS28和HAQ-DI相关。在直到2002年纳入的患者中,基线时疼痛程度更高的患者DAS28(DAS28每cm疼痛VAS为0.01单位/月,P = 0.024)下降得更快; 在2002年以后纳入的患者中,疼痛的影响更强(0.01单位/月,p = 0.087)。EMS越长,DAS28下降更多。在两组患者中,EMS持续时间较长的患者HAQ-DI(p = 0.006)下降更多,但疼痛和疲劳不是HAQ-DI变化的显著预测指标。

患者报告的基线时的疲劳、疼痛和僵硬对于预测RA疾病活动(DAS28)变化和活动受限(HAQ-DI)其价值有限。

原始出处:

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    2017-07-09 lmm397
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    2017-07-07 130****4638

    学习了谢谢分享

    0

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    2017-07-07 dhzzm

    学习了分享了

    0

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