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PLoS One:普洱茶减肥降脂机制可能与SREBP基因有关

2015-02-14 MedSci MedSci原创

喝普洱茶到底能不能减肥降脂?日前,中科院昆明动物研究所梁斌课题组与昆明学院副教授邹晓菊合作,通过实验证实了普洱茶的减肥降脂机制。相关研究近日发表在PLoS One上。云南普洱茶是由云南大叶种晒青毛茶经后发酵,包括自然发酵(非酶性氧化)和渥堆发酵(微生物酶促氧化)制成的发酵茶。普洱茶广受海内外欢迎的一个重要原因是:传统上认为它具有减肥、降脂、防止心血管疾病等多种保健功效。然而,对普洱茶诸多保健功能的

普洱茶包装


喝普洱茶到底能不能减肥降脂?日前,中科院昆明动物研究所梁斌课题组与昆明学院副教授邹晓菊合作,通过实验证实了普洱茶的减肥降脂机制。相关研究近日发表在PLoS One上。

云南普洱茶是由云南大叶种晒青毛茶经后发酵,包括自然发酵(非酶性氧化)和渥堆发酵(微生物酶促氧化)制成的发酵茶。普洱茶广受海内外欢迎的一个重要原因是:传统上认为它具有减肥、降脂、防止心血管疾病等多种保健功效。然而,对普洱茶诸多保健功能的科学研究却严重匮乏和滞后。

梁斌等研究人员采用模式生物——秀丽线虫,通过饲喂其不同浓度的普洱茶,结合薄层分析/气相色谱和脂肪染料Nile Red等,检测普洱茶对秀丽线虫脂肪含量的影响。

他们发现,经普洱茶水提物处理后,线虫脂滴明显变小,脂肪含量下降,证明普洱茶的确能降低秀丽线虫脂肪含量,具有减肥、降脂功效。

进一步分析发现,普洱茶处理后线虫的硬脂酸含量上升,油酸的含量下降。硬脂酰辅酶A去饱和酶(SCD)负责把饱和脂肪酸棕榈酸和硬脂酸分别转变为单不饱和脂肪酸棕榈油酸和油酸。普洱茶的确能显著降低线虫SCD以及调控SCD的转录因子SREBP的表达,进而抑制脂肪合成,降低脂肪含量,但其作用成分有待研究。

此外,该研究还指出,普洱茶虽然能抑制秀丽线虫进食和食物吸收,但对其生长发育、后代数目和寿命没有显著影响。

原始出处:

Ding Y, Zou X, Jiang X, Wu J, Zhang Y, Chen D, Liang B.Pu-Erh Tea Down-Regulates Sterol Regulatory Element-Binding Protein and Stearyol-CoA Desaturase to Reduce Fat Storage in Caenorhaditis elegans. PLoS One. 2015 Feb 6;10(2):e0113815.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1789642, encodeId=b5ee1e8964287, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Sat Nov 28 06:36:00 CST 2015, time=2015-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32162, encodeId=054a321629e, content=有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Jul 09 21:02:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16657, encodeId=d6601665e59, content=非常好的文章,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Sat Feb 21 10:45:00 CST 2015, time=2015-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16580, encodeId=e4fc16580c0, content=很不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Fri Feb 20 09:16:00 CST 2015, time=2015-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15670, encodeId=2e09156e0c2, content=以阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c68e1614119, createdName=windmilL1989, createdTime=Mon Feb 16 13:40:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402279, encodeId=0ff114022e9ec, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Mon Feb 16 01:36:00 CST 2015, time=2015-02-16, status=1, ipAttribution=)]
    2015-07-09 cmn

    有趣

    0

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    2015-02-21 orthoW

    非常好的文章,学习

    0

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    2015-02-20 orthoW

    很不错学习了

    0

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    2015-02-16 windmilL1989

    以阅

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1789642, encodeId=b5ee1e8964287, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Sat Nov 28 06:36:00 CST 2015, time=2015-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32162, encodeId=054a321629e, content=有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=161, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Jul 09 21:02:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16657, encodeId=d6601665e59, content=非常好的文章,学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Sat Feb 21 10:45:00 CST 2015, time=2015-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16580, encodeId=e4fc16580c0, content=很不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Fri Feb 20 09:16:00 CST 2015, time=2015-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15670, encodeId=2e09156e0c2, content=以阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c68e1614119, createdName=windmilL1989, createdTime=Mon Feb 16 13:40:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1402279, encodeId=0ff114022e9ec, content=<a href='/topic/show?id=862e8e196a1' target=_blank style='color:#2F92EE;'>#茶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87196, encryptionId=862e8e196a1, topicName=茶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/eTyQ1TyLVfyaGrflWSd1Jw4u1F68ibicmN32DE38FjEW3zTIKeFeaMUAQsjyqaL4QZ3lRibFIzziacMz9niceznOTTw/132, createdBy=03082405249, createdName=hbwxf, createdTime=Mon Feb 16 01:36:00 CST 2015, time=2015-02-16, status=1, ipAttribution=)]
    2015-02-16 hbwxf
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