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CSC：人类干细胞进行修复经放射治疗后的患脑癌大鼠

2015-02-10 MedSci MedSci原创

人类干细胞脑癌
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对于脑癌患者，辐射治疗是一项有效的的和强有力的抢救治疗方式，但它也可以对大脑引起相当大的甚至永久性伤害。如今，通过对大鼠进行临床前实验，纪念斯隆-凯特琳癌症中心的研究人员已经开发出一种方法，即把人类干细胞分化成被指示能够修复大脑受损的细胞。这项研究的主要内容是用人类干细胞对大鼠大脑经过放射治疗丢失认知和运动功后进行治疗。研究结果发表在2015年2月5日发行的Cell Stem Cell期刊中。

对于脑癌患者，辐射治疗是一项有效的的和强有力的抢救治疗方式，但它也可以对大脑引起相当大的甚至永久性伤害。如今，通过对大鼠进行临床前实验，纪念斯隆-凯特琳癌症中心的研究人员已经开发出一种方法，即把人类干细胞分化成被指示能够修复大脑受损的细胞。这项研究的主要内容是用人类干细胞对大鼠大脑经过放射治疗丢失认知和运动功后进行治疗。研究结果发表在2015年2月5日发行的Cell Stem Cell期刊中。

在对脑癌进行放射治疗期间，后来成熟的祖细胞在神经元周围产生的保护性髓鞘涂层丢失或者明显耗尽，并且没有可行性的治疗对其进行修复。这些被称为少突胶质细胞的髓鞘细胞，是在整个生命过程中屏蔽和修复大脑的神经元的关键。

在纽约市纪念斯隆-凯特林癌症中心，由神经外科医生Viviane Tabar和助理研究员朴京华博士带领的团队想知道干细胞是否可以取代这些丢失的少突胶质细胞的祖细胞。他们发现，这可以通过培养干细胞—来自皮肤活检的人类干细胞或诱导多能干细胞—以及在某种特定的细胞因子或其他分子的存在下就可以实现了。

接下来，研究人员使用实验室培养的少突胶质细胞祖细胞治疗在放射条件下暴露的大鼠的大脑。当这些细胞被注射到特定的大脑区域，大脑的修复是显而易见的，并且大鼠重新获得了由于暴露在放射条件下丢失的的认知和运动功能。而且治疗也是安全的，没有大鼠形成肿瘤，并且其大脑中也没有不适当的细胞类型出现。

Tabar医生说：“能够修复辐射损伤可能意味着两件重要的事情：提高幸存者的生活质量可能扩大辐射治疗窗。” 这将会被进一步证明，但如果我们能有效修复大脑，我们可以在一定限度内大胆的使用辐射剂量。这对儿童尤其重要，因为对于儿童而言，医生会故意提供更低的辐射剂量。

原始出处

Piao et al. Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.Cell Stem Cell, 2015

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  1. [GetPortalCommentsPageByObjectIdResponse(id=16593, encodeId=c5e4165931a, content=很不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Fri Feb 20 09:21:00 CST 2015, time=2015-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15776, encodeId=b60115e7608, content=以阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c68e1614119, createdName=windmilL1989, createdTime=Mon Feb 16 14:03:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391861, encodeId=22871391861de, content=<a href='/topic/show?id=085c8495615' target=_blank style='color:#2F92EE;'>#脑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84956, encryptionId=085c8495615, topicName=脑癌)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQHWdlyPWPmuHjfEXicudmC0dJ6SN5PHzglbDHibXpT1VXF2fKDnTzl2Eib4Pf94p58cnSKA3ZfGdFQ/132, createdBy=c44f2500101, createdName=ms2694732865965676, createdTime=Thu Feb 12 07:59:00 CST 2015, time=2015-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15328, encodeId=02d41532824, content=机理是什么, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=114.90.43.**, createdTime=Tue Feb 10 19:26:00 CST 2015, time=2015-02-10, status=1, ipAttribution=)]
    2015-02-20 orthoW

    很不错学习了

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=16593, encodeId=c5e4165931a, content=很不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Fri Feb 20 09:21:00 CST 2015, time=2015-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15776, encodeId=b60115e7608, content=以阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c68e1614119, createdName=windmilL1989, createdTime=Mon Feb 16 14:03:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391861, encodeId=22871391861de, content=<a href='/topic/show?id=085c8495615' target=_blank style='color:#2F92EE;'>#脑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84956, encryptionId=085c8495615, topicName=脑癌)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQHWdlyPWPmuHjfEXicudmC0dJ6SN5PHzglbDHibXpT1VXF2fKDnTzl2Eib4Pf94p58cnSKA3ZfGdFQ/132, createdBy=c44f2500101, createdName=ms2694732865965676, createdTime=Thu Feb 12 07:59:00 CST 2015, time=2015-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15328, encodeId=02d41532824, content=机理是什么, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=114.90.43.**, createdTime=Tue Feb 10 19:26:00 CST 2015, time=2015-02-10, status=1, ipAttribution=)]
    2015-02-16 windmilL1989

    以阅

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=16593, encodeId=c5e4165931a, content=很不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Fri Feb 20 09:21:00 CST 2015, time=2015-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15776, encodeId=b60115e7608, content=以阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c68e1614119, createdName=windmilL1989, createdTime=Mon Feb 16 14:03:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391861, encodeId=22871391861de, content=<a href='/topic/show?id=085c8495615' target=_blank style='color:#2F92EE;'>#脑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84956, encryptionId=085c8495615, topicName=脑癌)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQHWdlyPWPmuHjfEXicudmC0dJ6SN5PHzglbDHibXpT1VXF2fKDnTzl2Eib4Pf94p58cnSKA3ZfGdFQ/132, createdBy=c44f2500101, createdName=ms2694732865965676, createdTime=Thu Feb 12 07:59:00 CST 2015, time=2015-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15328, encodeId=02d41532824, content=机理是什么, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=114.90.43.**, createdTime=Tue Feb 10 19:26:00 CST 2015, time=2015-02-10, status=1, ipAttribution=)]
    2015-02-12 ms2694732865965676

    #脑癌#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=16593, encodeId=c5e4165931a, content=很不错学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Fri Feb 20 09:21:00 CST 2015, time=2015-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15776, encodeId=b60115e7608, content=以阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c68e1614119, createdName=windmilL1989, createdTime=Mon Feb 16 14:03:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391861, encodeId=22871391861de, content=<a href='/topic/show?id=085c8495615' target=_blank style='color:#2F92EE;'>#脑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84956, encryptionId=085c8495615, topicName=脑癌)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQHWdlyPWPmuHjfEXicudmC0dJ6SN5PHzglbDHibXpT1VXF2fKDnTzl2Eib4Pf94p58cnSKA3ZfGdFQ/132, createdBy=c44f2500101, createdName=ms2694732865965676, createdTime=Thu Feb 12 07:59:00 CST 2015, time=2015-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15328, encodeId=02d41532824, content=机理是什么, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=114.90.43.**, createdTime=Tue Feb 10 19:26:00 CST 2015, time=2015-02-10, status=1, ipAttribution=)]
    2015-02-10 114.90.43.**

    机理是什么

    0

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