JCEM：运动是如何影响脂肪分解的？

2017-06-16 MedSci MedSci原创

尽管对脂肪组织中脂肪分解的机制研究越来越多，但运动对脂肪分解的各个因素的影响仍不太清楚。因此，来自希腊的研究人员，在肥胖人群和苗条人群的运动过程中比较了：脂肪组织中的甘油三酯脂肪酶的活性和脂肪甘油三酯脂肪酶（ATGL）基因表达、激素敏感脂肪酶（HSL）、单酰甘油脂肪酶（MGL）、perilipin 1蛋白、CGI-58基因的变化。7名身材苗条者和9名肥胖者骑行了30分钟（心率为130-140/mi

尽管对脂肪组织中脂肪分解的机制研究越来越多，但运动对脂肪分解的各个因素的影响仍不太清楚。因此，来自希腊的研究人员，在肥胖人群和苗条人群的运动过程中比较了：脂肪组织中的甘油三酯脂肪酶的活性和脂肪甘油三酯脂肪酶（ATGL）基因表达、激素敏感脂肪酶（HSL）、单酰甘油脂肪酶（MGL）、perilipin 1蛋白、CGI-58基因的变化。

本研究中，7名身材苗条者和9名肥胖者骑行30分钟（心率为130-140/min），研究人员采样了在运动基线和5min, 10min, 20min，30min时的皮下脂肪组织和血样，进而测定了相应时间的甘油三酯脂肪酶活性、mRNA（脂肪组织）以及甘油三酯、游离脂肪酸（NEFA）、葡萄糖、乳酸、胰岛素、儿茶酚胺（血样）。

研究人员发现，在苗条者运动十min时，甘油三酯脂肪酶活性升高，在20min和30min检测时又恢复到基线水平。在肥胖人群中，在10min、20min、30min检测的甘油三酯脂肪酶活性均高于基线水平，且高于苗条者在20和30min时的水平。在运动过程中没有发现mRNA水平的变化，但肥胖者ATGL、HSL和CGI-58的mRNA表达水平比苗条者低。

该研究结果表明，身材苗条和肥胖男性在进行耐力运动时，其脂肪分解的模式不同。脂肪分解的速度差异似乎是由于蛋白质的数量或活性差异导致的，并不是mRNA水平。

原始出处：

Petridou A, Chatzinikolaou A,et al.Increased Triacylglycerol Lipase Activity in Adipose Tissue of Lean and Obese Men During Endurance Exercise.J Clin Endocrinol Metab. 2017 Jun 12. doi: 10.1210/jc.2017-00168. [Epub ahead of print]

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2018-02-23 achengzhao

#JCE#

74 0
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2018-04-08 canlab

#脂肪分解#

78 0
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2018-01-13 smallant2015

#JCEM#

86 0
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2017-06-22 1e10c84am36(暂无匿称)

文章很好，拜读了

131 0
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2017-06-21 lou.minghong

学习了，谢谢分享！

108 0
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2017-06-18 1861f05a42m

期待下一步数据

134 0
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2017-06-18 luominglian113

学习了，谢谢分享

0 0
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2017-06-17 1e0d2fb7m34(暂无匿称)

搞糊涂了，那是和什么有关

152 0
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2017-06-17 186****0580(小山羊）

学习了谢谢了。

66 0
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2017-06-17 flyingzyx

学习了，谢谢分享。

68 0