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JCEM:骨质疏松症与帕金森氏病风险的关系

2020-11-25 MedSci原创 MedSci原创

骨质疏松症与PD风险增加有关,尤其是女性。

骨质疏松症和帕金森氏症(PD)经常并发,即使是早期PD患者,其骨密度水平也可能降低。这可能意味着骨质疏松症与较高的PD风险有关。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在明确骨质疏松症患者随后患PD的风险是否升高。

研究人员使用台湾国家健康保险研究数据库进行了回顾性队列研究。骨质疏松症组共纳入了23495名年龄在50至80岁之间且在2002年至2006年之间患有骨质疏松症的受试者。对照组纳入了23495名没有骨质疏松症的倾向评分匹配患者。他们的倾向得分是使用Logistic回归模型计算的,该模型包括年龄、性别、合并症和社会经济状况。

骨质疏松症组发生PD的风险比(HR)是对照组的1.31倍(95%CI:1.13-1.50,p=0.0002)。骨质疏松症组的无PD生存率也明显低于对照组(p=0.0004)。按性别分层的分析表明,骨质疏松症妇女患PD的HR(HR为1.50,95%CI:1.27-1.77,p<0.0001)似乎比男性(HR为1.23,95%CI:0.93-1.64),p=0.15)高。

本研究结果表明,骨质疏松症与PD风险增加有关,尤其是女性。

原始出处:

Shih-Hao Feng.et al.Osteoporosis and the risk of Parkinson’s disease: A nationwide propensity score-matched longitudinal follow-up study.JCEM.2020.https://doi.org/10.1210/clinem/dgaa864

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    2021-10-13 smallant2015
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createdBy=42435426428, createdName=ms8000001080131379, createdTime=Thu Dec 17 20:10:07 CST 2020, time=2020-12-17, status=1, ipAttribution=)]
    2021-09-14 xieqian_78

    !!!!

    0

  4. 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createdBy=42435426428, createdName=ms8000001080131379, createdTime=Thu Dec 17 20:10:07 CST 2020, time=2020-12-17, status=1, ipAttribution=)]
    2020-12-02 lifefamily@163

    #骨质疏松症##帕金森氏病#风险增加有关,尤其是女性,我个人认为这个结论不可靠。尤其是女性,这两种疾病背后是同一个原因,#雌激素#水平下降,机体呈现#退行性病变#。它们可能是并行的关系,而不是因果关系,只是骨质疏松严重的人,帕金森氏病可能概率也会高一些而已。

    1

    展开1条回复
  5. 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href='/topic/show?id=c55098e5612' target=_blank style='color:#2F92EE;'>#雌激素#</a>水平下降,机体呈现<a href='/topic/show?id=45719468e93' target=_blank style='color:#2F92EE;'>#退行性病变#</a>。它们可能是并行的关系,而不是因果关系,只是骨质疏松严重的人,帕金森氏病可能概率也会高一些而已。, beContent=null, objectType=article, channel=null, level=null, likeNumber=262, replyNumber=1, topicName=null, topicId=null, topicList=[TopicDto(id=101869, encryptionId=e59810186916, topicName=骨质疏松症), TopicDto(id=48514, encryptionId=4e334851457, topicName=帕金森氏病), TopicDto(id=98756, encryptionId=c55098e5612, topicName=雌激素), TopicDto(id=94687, encryptionId=45719468e93, topicName=退行性病变)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily@163, createdTime=Wed Dec 02 11:44:43 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=970558, encodeId=95d99e0558f5, content=<a 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createdBy=42435426428, createdName=ms8000001080131379, createdTime=Thu Dec 17 20:10:07 CST 2020, time=2020-12-17, status=1, ipAttribution=)]
    2021-06-03 CWRCWR

    #骨质疏松#如何预防

    1

    展开1条回复
  6. 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createdBy=42435426428, createdName=ms8000001080131379, createdTime=Thu Dec 17 20:10:07 CST 2020, time=2020-12-17, status=1, ipAttribution=)]
    2021-03-02 achengzhao
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    2021-01-27 ms9000000710729683

    #学习#学习了

    0

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createdBy=e656479, createdName=achengzhao, createdTime=Tue Mar 02 11:22:36 CST 2021, time=2021-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920270, encodeId=78f59202e0f2, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=15a85438556, createdName=ms9000000710729683, createdTime=Wed Jan 27 12:20:05 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920269, encodeId=490f92026918, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, 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    2021-01-14 ms9000000710729683

    学习了

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1777999, encodeId=7cde1e7799916, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Wed Oct 13 00:22:36 CST 2021, time=2021-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820425, encodeId=b75518204258b, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, 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    2020-12-17 ms8000001080131379

    学习了

    0

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