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Trends in Parasitology:研究人员质疑弓形体病终身免疫

2016-12-27 张章 科学网

通常,书本这样教给医学院学生:一旦感染过弓形虫—— 一种猫科动物寄生虫,那么你就不会再感染。日前,法美研究人员在《寄生虫学趋势》期刊上发文质疑了这一教条。 弓形虫免疫检测结果阳性的人数量一直在下降,这让科学家迷惑不解。这种寄生虫感染率的不确定性部分由于报告稀少。除免疫功能不全者外,很少有人经历过不良反应。进入身体后,这种单细胞寄生虫会沿血液进入大脑和肌肉,并形成囊孢。研究人员认为这些囊孢会

通常,书本这样教给医学院学生:一旦感染过弓形虫—— 一种猫科动物寄生虫,那么你就不会再感染。日前,法美研究人员在《寄生虫学趋势》期刊上发文质疑了这一教条。

弓形虫免疫检测结果阳性的人数量一直在下降,这让科学家迷惑不解。这种寄生虫感染率的不确定性部分由于报告稀少。除免疫功能不全者外,很少有人经历过不良反应。进入身体后,这种单细胞寄生虫会沿血液进入大脑和肌肉,并形成囊孢。研究人员认为这些囊孢会永远停留着感染着体内,而它们的存在会触发免疫系统。

但法国里昂红十字医院寄生虫学家François Peyron及其合作者并不这么认为。他们的观点起源于少量个案研究,孕妇在孕期20周末期到30周初期感染弓形虫,但分娩后实际被没有产生免疫保护。该研究组计划跟踪数百位感染者,以确定何时及谁的弓形虫免疫可能逐渐减弱。以便获得更多的证据支持该假设。

对于孕妇而言,弓形虫危害极大,可能导致妊娠终止或胎儿畸形。法国等一些国家通常会对没有感染弓形虫病史的孕妇进行常规筛查。但如果有证据显示感染过弓形虫后仍可能再次感染,那么针对孕妇的常规检查标准就需要修改。他们还建议所有孕妇遵循避免弓形虫感染的指导方针,例如勤洗手。

原始出处

Solène Rougier, Jose G. Montoya.Lifelong Persistence of Toxoplasma Cysts: A Questionable Dogma? Trends in Parasitology.2016

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    2017-11-26 gaoxiaoe
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    2017-12-04 freve
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    2017-06-03 saikp
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    2017-06-09 智慧医人

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