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J Endod:255-nm发光二极管能够杀死粪肠球菌并诱导人胚胎腭间充质细胞和牙龈成纤维细胞的生物标记物

2019-04-28 lishiting MedSci原创

感染或炎症牙髓组织的成功治疗需要对根管区域的物理化学清创并严密封闭冠方和根尖方开口。仅有几种方法能够清除局部组织的感染或激活再生。这篇研究的目的是为了评估255-nm和405-nm发光二极管(LED)杀灭粪肠球菌以及诱导牙髓组织再生相关细胞标记物的能力。

感染或炎症牙髓组织的成功治疗需要对根管区域的物理化学清创并严密封闭冠方和根尖方开口。仅有几种方法能够清除局部组织的感染或激活再生。这篇研究的目的是为了评估255-nm和405-nm发光二极管(LED)杀灭粪肠球菌以及诱导牙髓组织再生相关细胞标记物的能力。

研究检验了255-nm和405-nm LED对粪肠球菌的抗菌效果,以及对人胚胎腭间充质 (HEPM) 细胞和牙龈成纤维细胞骨诱导、成血管、增殖和促炎症反应相关生物标记物的影响。

结果显示,255-nm LED能够杀灭粪肠球菌,而不是405-nm LED;255-nm LED联合次氯酸钠能够更有效的杀灭粪肠球菌;255-nm和405-nm LED均不会影响HEPM细胞和牙龈成纤维细胞的活性;单独使用255-nm LED或联合使用405-nm LED能够诱导HEPM细胞和牙龈成纤维细胞牙髓组织再生相关生物标记物的表达。

结论:这篇研究结果表明,这种全新的短暂应用255-nm LED可作为物理化学清创的辅助疗法不仅能够在炎症部位去感染,还可以诱导牙髓组织再生相关生物标记物的产生。

原始出处:

Morio K, Thayer EL, et al. 255-nm Light-emitting Diode Kills Enterococcus faecalis and Induces the Production of Cellular Biomarkers in Human Embryonic Palatal Mesenchyme Cells and Gingival Fibroblasts. J Endod. 2019 Mar 28. pii: S0099-2399(19)30125-6. doi: 10.1016/j.joen.2019.02.016.

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    2019-11-05 wjywjy
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time=2019-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531243, encodeId=77af15312433b, content=<a href='/topic/show?id=3b5ee633753' target=_blank style='color:#2F92EE;'>#粪肠球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76337, encryptionId=3b5ee633753, topicName=粪肠球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f72712226339, createdName=hb2012ye, createdTime=Tue Apr 30 07:01:00 CST 2019, time=2019-04-30, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1904523, encodeId=0644190452396, content=<a href='/topic/show?id=b8aa619690e' target=_blank style='color:#2F92EE;'>#标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61969, encryptionId=b8aa619690e, topicName=标记物)], attachment=null, authenticateStatus=null, createdAvatar=/img/user_icon.png, createdBy=1072181, createdName=wjywjy, createdTime=Tue Nov 05 05:01:00 CST 2019, time=2019-11-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989651, encodeId=97a4198965114, content=<a href='/topic/show?id=541c239345a' target=_blank style='color:#2F92EE;'>#二极管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23934, encryptionId=541c239345a, topicName=二极管)], attachment=null, authenticateStatus=null, createdAvatar=, 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time=2019-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531243, encodeId=77af15312433b, content=<a href='/topic/show?id=3b5ee633753' target=_blank style='color:#2F92EE;'>#粪肠球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76337, encryptionId=3b5ee633753, topicName=粪肠球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f72712226339, createdName=hb2012ye, createdTime=Tue Apr 30 07:01:00 CST 2019, time=2019-04-30, status=1, ipAttribution=)]
    2019-04-30 ailian1202
  6. 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  7. 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  8. 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  9. 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