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JACC:冠脉微血管功能不良可作为肥胖患者的心血管风险分层因子

2018-08-08 MedSci MedSci原创

除了体重指数(BMI)外,尚需要其他的因素来鉴别肥胖患者的心血管风险。本研究的目的旨在评估肥胖、冠脉微血管功能不良(CMD)和不良反应事件的相关性。本研究对827名心脏灌注正电子发射断层显像显示正常灌注的肥胖患者进行平均5.6年时间的随访,观察事件主要包括死亡、心梗或心衰住院。分析结果显示,BMI与冠脉血流储备(CFR)呈倒J型曲线相关,即在肥胖患者中,CFR随着BMI的升高而降低(p <

除了体重指数(BMI)外,尚需要其他的因素来鉴别肥胖患者的血管风险。本研究的目的旨在评估肥胖、冠脉微血管功能不良(CMD)和不良反应事件的相关性。

本研究对827名心脏灌注正电子发射断层显像显示正常灌注的肥胖患者进行平均5.6年时间的随访,观察事件主要包括死亡、心梗或心衰住院。分析结果显示,BMI与冠脉血流储备(CFR)呈倒J型曲线相关,即在肥胖患者中,CFR随着BMI的升高而降低(p < 0.0001),经调整分析后发现,CFR与不良反应事件呈相关性,而BMI不是。在肥胖患者中,CFR下降的患者发生不良反应事件的风险更高(5.7% vs. 2.6%; p = 0.002),即使在没有达到减肥手术要求的患者中也是如此(6.4% vs. 2.6%; p = 0.04)。

本研究结果显示,在肥胖患者中,冠脉微血管功能不良与升高的BMI和不良反应事件的发生率相关,且在危险分层方面优于BMI。

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    2018-10-01 hbwxf
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    2018-08-10 mgqwxj
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