Neurology：糖尿病与后续帕金森病之间的关系

2018-06-14 xing.T MedSci原创

由此可见，在这项大型队列研究中，研究人员报告了T2DM后PD的发生率有所增加。这些发现可能反映了他们可能共享遗传易感性和/或共享致病途径，这些结果具有潜在的临床和治疗意义。

近日，神经病学领域权威取杂志Neurology上发表了一篇研究文章，研究人员旨在探讨2型糖尿病（T2DM）与后续帕金森病（PD）之间的关系。

研究人员采用英国国立医院统计和死亡率数据（1999-2011）进行了一项回顾性队列研究，构建了一个接受治疗的T2DM队列，并与参考队列进行了比较。研究人员使用Cox回归模型估计了随后的PD风险。排除了脑血管疾病、血管性帕金森综合征、药物性帕金森综合征和正常压力脑积水的个体。

该研究共有2017115人进入了T2DM队列，6173208人进入了参考队列。T2DM后PD发生率显著升高（风险比[HR] 为1.32，95%可信区间[CI]为1.29-1.35；P＜0.001）。当与较年轻的个体相比（25-44岁组，HR为3.81、95%CI为2.84-5.11），复杂T2DM患者（HR为1.49、95%CI为1.42-1.56）相对增加程度更大。

由此可见，在这项大型队列研究中，研究人员报告了T2DM后PD的发生率有所增加。这些发现可能反映了他们可能共享遗传易感性和/或共享致病途径，这些结果具有潜在的临床和治疗意义。

原始出处：

Eduardo De Pablo-Fernandez,et al. Association between diabetes and subsequent Parkinson disease A record-linkage cohort study.neurology.2018. https://doi.org/10.1212/WNL.0000000000005771

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2022-05-01 病毒猎手

#糖尿病#与后续#帕金森病#

190 0
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2018-08-31 yinhl1978

#Neurol#

82 0
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2018-06-20 phoebeyan520

学习了.谢谢分享

107 0
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2018-06-15 1209e435m98(暂无昵称)

学习了.谢谢分享

121 0
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2018-06-15 飛歌

厉害了我的哥

112 0
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2018-06-14 清风拂面

谢谢分享学习

103 0
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2018-06-14 changjiu

学习一下谢谢

100 0
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