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J Heart Lung Transplant:冠心病患者移植后的长期生存优于非冠心病患者??

2016-07-23 phylis 译 MedSci原创

背景:充血性心脏疾病(CHD)成人移植受者的死亡率和发病率的研究是有限的。研究者进行系统的回顾和荟萃分析比较2个群体的移植后的预后。方法:进行电子数据库搜索后,研究者选择评估冠心病与非冠心病患者,死亡率,特定的死亡率以及再手术和透析的风险。研究者使用随机效应模型进行荟萃分析。结果:与非CHD患者相比,CHD患者30天死亡率明显升高(RR,2.18;95% CI,1.62-2.93;I2 = 41%

背景:充血性心脏疾病(CHD)成人移植受者的死亡率和发病率的研究是有限的。研究者进行系统的回顾和荟萃分析比较2个群体移植后的预后。

方法:进行电子数据库搜索后,研究者选择评估冠心病与非冠心病患者的死亡率、特定的死亡率以及再手术和透析的风险。研究者使用随机效应模型进行荟萃分析。

结果:与非CHD患者相比,CHD患者30天死亡率明显升高(RR,2.18;95% CI,1.62-2.93;I2 = 41%)。与非CHD患者相比,是由于Fontan /Glenn患者的死亡率升高所影响。CHD患者1年和5年的死亡率升高,尽管没有统计学意义(RR,3.3;95% CI,1.89-5.77;I2 = 0%)。。CHD患者10年的死亡率显著降低(RR,0.75;95% CI,0.60-0.95,I2 = 42%)。冠心病患者恶性肿瘤、感染、排斥反应与移植心脏血管病引起的死亡减少,虽然只有恶性肿瘤引起的死亡有显著的差异。冠心病患者中原发性移植失败,卒中和出血的继发性死亡显著升高。两组中再次手术和透析的风险差异无统计学意义。

结论:尽管成人CHD患者早期死亡率高,但移植后的长期生存优于非冠心病患者。

原始出处:

Doumouras BS, Alba AC, et al. Outcomes in adult congenital heart disease patients undergoing heart transplantation: A systematic review and meta-analysis. J Heart Lung Transplant. 2016 Jun 7


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    2017-03-03 zhaojie88
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    2017-01-09 bsmagic9140
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    2016-09-25 1e10c84am36(暂无匿称)

    文章很好值得关注

    0

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    2016-07-25 zhaojie88
  6. [GetPortalCommentsPageByObjectIdResponse(id=1796120, encodeId=1aed1e96120a4, content=<a href='/topic/show?id=691c1e765a0' target=_blank style='color:#2F92EE;'>#Transplant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17765, encryptionId=691c1e765a0, topicName=Transplant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=232a2500033, createdName=1249859em38(暂无昵称), createdTime=Sat Jun 03 14:39:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789135, encodeId=7b7e1e89135c1, content=<a href='/topic/show?id=0c8814344f5' target=_blank style='color:#2F92EE;'>#plant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14344, encryptionId=0c8814344f5, topicName=plant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 03 10:39:00 CST 2017, time=2017-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1656712, encodeId=9e441656e12e9, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Mon Jan 09 10:39:00 CST 2017, time=2017-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135106, encodeId=bbe2135106dc, content=文章很好值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 25 17:20:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356094, encodeId=7acc1356094cc, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 25 03:39:00 CST 2016, time=2016-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447680, encodeId=4ce0144e6801a, content=<a href='/topic/show?id=523a3082670' target=_blank style='color:#2F92EE;'>#冠心病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30826, encryptionId=523a3082670, topicName=冠心病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99445365987, createdName=liubm557, createdTime=Mon Jul 25 03:39:00 CST 2016, time=2016-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562378, encodeId=6a4715623e873, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Jul 25 03:39:00 CST 2016, time=2016-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1618295, encodeId=af4216182952f, content=<a href='/topic/show?id=3ebc9e0210b' target=_blank style='color:#2F92EE;'>#长期生存#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97021, encryptionId=3ebc9e0210b, topicName=长期生存)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1f719885829, createdName=luckyshitiancai_42705690, createdTime=Mon Jul 25 03:39:00 CST 2016, time=2016-07-25, status=1, ipAttribution=)]
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    2016-07-25 slcumt
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冠状动脉粥样硬化性心脏病是指由于 冠状动脉粥样硬化使管腔狭窄、痉挛或阻塞导致心 肌缺血、缺氧或坏死而引发的心脏病,统称为冠状 动脉性心脏病或冠状动脉疾病,简称冠心病,归属 为缺血性心脏病,是动脉粥样硬化导致器官病变的 最常见类型。我国冠心病流行情况 根据最新发布的《中 国心血管病报告 2014》显示,我国心血管疾病流 行趋势明显,导致心血管疾病发病人数增加。总体 上看,我国心血管疾病患病率及死

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