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Clin Trans Gastroenterology:代谢综合征患者接受长期运动训练可以改善肝脏纤维化和炎症

2021-06-26 MedSci原创 MedSci原创

代谢综合征 (MetS) 是世界范围内的主要健康问题,也是代谢相关性脂肪肝 (MAFLD) 的主要危险因素。目前的治疗方案是建议患者改变饮食和增加身体活动。

      代谢综合征 (MetS) 是世界范围内的主要健康问题,也是代谢相关性脂肪肝 (MAFLD) 的主要危险因素。目前的治疗方案是建议患者改变饮食和增加身体活动。在本项研究中,研究人员运动训练干预对 MetS 患者肝脏炎症和纤维化参数的影响。

 

      这是一项前瞻性、随机双盲研究。被诊断出 MetS 的参与者被随机分配 (1:1) 到为期 6 个月的生活方式干预组,本项研究的关键是监督、并指导活动锻炼。然后再对肝酶和 MAFLD 相关参数进行了评估。

 

      研究人员在2017年10月10日至2018年2月27日期间筛选了543名个体,其中 314 名被随机分配到干预组(n = 160)或对照组(n = 154)。与对照组相比,干预组6个月后的肝转氨酶、碱性磷酸酶和γ-谷氨酰转移酶显着降低。此外,作为肝纤维化标志物的天冬氨酸转氨酶与血小板比率指数评分在干预组中显着降低。而这些改善与肥胖和运动能力的变化有关。

图:运动对于代谢综合征的影响

 

       本项研究证实了为期 6 个月的基于运动训练的生活方式干预可以改善了MetS 患者的肝脏炎症和纤维化指标。因此,这种干预显示了对 MAFLD 高风险个体的治疗潜力。

 

 

原始出处:

Haufe, Sven. Et al. Telemonitoring-Supported Exercise Training in Employees With Metabolic Syndrome Improves Liver Inflammation and Fibrosis. Clin Trans Gastroenterology.2021.

 

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    2021-11-06 许安
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    2021-12-26 bsmagic9140
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