CANCER RES；靶向TBX2-WNT信号的路治疗前列腺癌骨转移

2017-03-26 xingxiaowei MedSci原创

对于晚期前列腺癌患者，找到肿瘤细胞骨转移以及后续骨重塑的影响因素对于肿瘤治疗有重要的意义。TBX2是T-box家族的转录因子，可以负向调节细胞周期抑制剂p21，在胚胎发育过程中扮演关键角色。研究表明其在肿瘤病程中同样起到重要作用。

对于晚期前列腺癌患者，找到肿瘤细胞骨转移以及后续骨重塑的影响因素对于肿瘤治疗有重要的意义。TBX2是T-box家族的转录因子，可以负向调节细胞周期抑制剂p21，在胚胎发育过程中扮演关键角色。研究表明其在肿瘤病程中同样起到重要作用。

近期发表在CANCER RES上的一篇文章研究了TBX2在前列腺癌中的作用。作者发现在前列腺癌鼠模型中，前列腺癌组织以及骨转移组织TBX2表达上升。在PC3和ARCaPM前列腺癌细胞模型的体外实验中阻断内源性TBX表达会抑制肿瘤细胞增殖、集落形成以及肿瘤细胞侵袭。在人前列腺癌异种移植鼠模型上阻断内源性的TBX2可以降低肿瘤的侵袭能力、骨消融和软组织转移能力。在骨转移瘤小鼠模型中，阻断前列腺癌肿瘤细胞内源性的TBX2可以抑制肿瘤细胞生长从而显着改善骨定植以及骨重塑情况。WNT信号途径与前列腺癌进展与骨转移有关，该研究证实了TBX2正是通过调节其下游的WNT3A进而前列腺肿瘤细胞生长产生影响。

作者认为这一新发现的TBX2-WNT3A信号途径可作为前列腺癌骨转移的治疗理想的靶向途径，为前列腺癌骨转移的治疗提供新的思路。

原始出处：

Srinivas Nandana,Manisha Tripathi,et al.Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at The TBX2-WNT Signaling Axis.CANCER RES.March 2017 doi:10.1158/0008-5472.CAN-16-0497

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2017-09-12 jjjiang0210

#Wnt信号#

76 0
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2017-03-28 zhwj

#WNT#

72 0
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2017-03-27 wxl882001

学习一下

99 0
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2017-03-26 虈亣靌

学习了谢谢作者分享!

113 0
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2017-03-26 喜婷

学习了

0 0
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2017-03-26 1e1c0c66m00(暂无匿称)

好好好

89 0
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2017-03-26 1ddf0692m34(暂无匿称)

探索医学奥秘

84 0
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2017-03-26 lovetcm

这还是基础研究，最终还要临床验证

56 0

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