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Crit Care:急性肾功能不全的患病率及其对COVID-19的影响

2020-06-21 MedSci原创 MedSci原创

COVID-19患者异常尿液分析和肾功能不全的发生率很高,并且AKI与COVID-19患者的严重程度和预后密切相关。因此,需要提高COVID-19患者对肾功能不全的认识。

近日,危重病医学领域权威杂志Critical Care上发表了一篇研究文章,该研究旨在评估COVID-19患者的异常尿液分析和肾功能不全的患病率,并确定急性肾损伤(AKI)与COVID-19患者的严重程度和预后之间的关系。

研究人员检索了Embase和PubMed电子数据库以确定相关研究。对符合条件的研究进行荟萃分析,这些研究报告了COVID-19患者尿液分析异常和肾功能不全的患病率。研究人员比较了严重和非严重患者与幸存者与非幸存者之间AKI的发生率。

该分析总共纳入了24项研究,累计4963例确诊的COVID-19患者。sCr和BUN水平升高的患者比例分别为9.6%(95%CI为5.7–13.5%)和13.7%(95%CI为5.5–21.9%)。在所有患者中,蛋白尿症占57.2%(95%CI为40.6–73.8%),蛋白尿+占38.8%(95%CI为26.3–51.3%),蛋白尿++或+++10.6%(95%CI为7.9-13.3%)。所有COVID-19患者的AKI总体发生率为4.5%(95%CI为3.0–6.0%),而在轻度或中度,重度和危重病例中AKI的发生率分别为1.3%(95%CI为0.2–2.4%)、2.8%(95%CI为1.4–4.2%)和36.4%(95%CI为14.6–58.3%)。同时,在非幸存者和幸存者中AKI的发生率分别为52.9%(95%CI为34.5-71.4%)和0.7%(95%CI为0.3-1.8%)。 5.6%(95%CI为2.6–8.6%)的重症患者、0.1%(95%CI为0.1-0.2%)的非严重患者和15.6%(95%CI为10.8–20.5%)的非幸存者和0.4%(95%CI为0.2-1.0%)的幸存者需要连续肾脏替代疗法(CRRT) 。

由此可见,COVID-19患者异常尿液分析和肾功能不全的发生率很高,并且AKI与COVID-19患者的严重程度和预后密切相关。因此,需要提高COVID-19患者对肾功能不全的认识。

原始出处:

Xianghong Yang.et al.Prevalence and impact of acute renal impairment on COVID-19: a systematic review and meta-analysis.Critical Care.2020.https://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03065-4

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