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Circulation子刊:PCI治疗急性冠脉综合征患者输血和急性肾损伤的危险性分析

2016-10-05 xing.T MedSci原创

由此可见,输血与接受PCI治疗的急性冠状动脉综合征患者的AKI发生密切相关,需要进一步的研究来确定是否限制性输血策略可能通过降低AKI风险改善PCI的预后。

急性肾损伤(AKI)合并冠状动脉介入治疗(PCI)往往与不良的临床预后联系在一起,到目前为止,没有研究评估接受PCI治疗的患者输血与AKI之间的关系,最近,心血管领域权威杂志《Circulation: Cardiovascular Interventions》上发表了一项研究成果,旨在对PCI治疗急性冠脉综合征患者输血及急性肾损伤的危险性进行分析。

研究者采用回顾性队列研究,纳入的所有参与者取自CathPCI注册表(n=1756864)中接受PCI治疗的急性冠状动脉综合征患者,主要指标是AKI,其定义为PCI术后血清肌酐上升≥0.5mg/dL或≥25%以上。


在研究对象中AKI的发生率为9%,AKI患者的年龄较大,女性较多,有高患病率的合并症,包括糖尿病、高血压、和晚期慢性肾脏疾病。2.2%的患者需要输血,在全部研究对象中,那些接受输血的患者AKI发生率为35.1%,而未输血患者发生AKI为8.4%(调整后的比值比为4.87 [4.71–5.04])。在那些有持续出血事件和输血的患者亚组中,AKI发生率显着增加;在无出血事件的患者的亚组中也有类似的发现。

由此可见,输血与接受PCI治疗的急性冠状动脉综合征患者的AKI发生密切相关,需要进一步的研究来确定是否限制性输血策略可能通过降低AKI风险改善PCI的预后。

原始出处:

Wassef Karrowni, et al. Blood Transfusion and the Risk of Acute Kidney Injury Among Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.
Circulation: Cardiovascular Interventions. 2016;9:e004950.

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    2016-10-11 1e10c84am36(暂无匿称)

    好文章,受益

    0

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    2016-10-07 windight
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    2016-10-05 1e0d99ddm02(暂无匿称)

    输血注意事项很多!

    0

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    2016-10-05 1e0d99ddm02(暂无匿称)

    分享一下!!

    0

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