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Int J Clin Pract:布洛芬/伪麻黄碱治疗普通感冒 这些影响因素要注意!

2017-04-10 常路 环球医学

普通感冒是最常见的急性呼吸道感染性疾病。2017年2月,发表在《Int J Clin Pract》的一项研究探讨了可影响非处方药布洛芬/伪麻黄碱复方制剂治疗普通感冒症状有效性的因素。请看本期多学科讨论组临床药师各抒己见为您梳理本文看点——目的:本研究的目的为探讨可影响非处方药布洛芬/伪麻黄碱复方制剂治疗普通感冒症状有效性的因素。方法:1770名购买复合制剂治疗自身普通感冒症状的药品消费者的匿名调查

普通感冒是最常见的急性呼吸道感染性疾病。2017年2月,发表在《Int J Clin Pract》的一项研究探讨了可影响非处方药布洛芬/伪麻黄碱复方制剂治疗普通感冒症状有效性的因素。请看本期多学科讨论组临床药师各抒己见为您梳理本文看点——

目的:本研究的目的为探讨可影响非处方药布洛芬/伪麻黄碱复方制剂治疗普通感冒症状有效性的因素。

方法:1770名购买复合制剂治疗自身普通感冒症状的药品消费者的匿名调查数据用于事后描述性分析。研究人员分析了通常对布洛芬有应答(头痛、咽痛、关节痛和发烧)的症状评分、通常对伪麻黄碱有应答(鼻塞、鼻塞充血、流鼻涕)的症状评分、认为非特异性(打喷嚏、疲劳、干咳、咳痰)的症状评分、包括所有11个症状的症状评分。多元回归分析用于探讨与更多的症状强度降低或更高概率的出现症状评分至少降低50%相关的因素。

结果:首次药物摄入后,典型布洛芬敏感性症状评分、对伪麻黄碱具有应答的症状评分、非特异性症状评分、总症状评分分别降低60.0%、46.3%、45.4%和52.8%。分别有73.6%、55.1%、50.9%和61.6%的参与者表示症状评分至少降低50%。较高的基线评分与较多的症状评分降低相关,但是实现至少改善50%的概率较小。两种多元回归方法间,首次给药2片比1片更有效,并且除了布洛芬敏感性症状评分外,感冒2天后开始治疗一般不太有效。

讨论和结论:布洛芬/伪麻黄碱联用治疗普通感冒症状的有效性为剂量依赖性,当症状发作后的最初两天开始治疗时,其有效性最高。

多学科讨论记实:

感冒目前尚无特效的抗病毒药物,故以对症治疗、缓解感冒症状为主,同时注意休息、适当补充水分、保持室内空气流通,避免继发细菌感染。普通感冒的药物治疗应以对症治疗药物为主。

基于1770名购买复合制剂(含有布洛芬200 mg和伪麻黄碱30 mg)治疗自身普通感冒症状的药品消费者队列,已经显示出与安慰剂对照研究相当的总体有效效和耐受性数据。本研究和既往研究表明,对药品消费者的调查可以成为科学信息的宝贵来源,特别是非处方药产品。所调查的复方制剂的治疗效果不依赖于患者的性别和体重以及年龄组别相似。预期地,基线症状强度对改善程度有很大的影响。疗效表现出预期的剂量依赖性,并且在感冒早期开始治疗时效果更好。

原始出处:

Klimek L, Schumacher H, Schütt T,et al.Factors associated with efficacy of an ibuprofen/pseudoephedrine combination drug in pharmacy customers with common cold symptoms. International Journal of Clinical Practice, 2017, 71(2).

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    2018-02-10 songbq
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    2017-04-11 dilshat910

    学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1924933, encodeId=22cc19249337b, content=<a href='/topic/show?id=51d359969ac' target=_blank style='color:#2F92EE;'>#普通感冒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59969, encryptionId=51d359969ac, topicName=普通感冒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754b42, createdName=Luyuxie_9, createdTime=Sun Jan 07 22:36:00 CST 2018, time=2018-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968920, encodeId=c9e519689205e, content=<a href='/topic/show?id=13d010310690' target=_blank style='color:#2F92EE;'>#麻黄碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103106, encryptionId=13d010310690, topicName=麻黄碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=856b247, createdName=songbq, createdTime=Sat Feb 10 09:36:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465535, encodeId=12ee146553524, content=<a href='/topic/show?id=144f5032688' target=_blank style='color:#2F92EE;'>#影响因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50326, encryptionId=144f5032688, topicName=影响因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80a06745918, createdName=chenzhuanggui, createdTime=Wed Apr 12 07:36:00 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186622, encodeId=500a18662257, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/d2ed7ec88067f7d4e256d4ab466d69b4/90f3cc295877498e263e9cdd0ae18ae8.jpg, createdBy=33ea1989011, createdName=dilshat910, createdTime=Tue Apr 11 10:00:16 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186597, encodeId=e9ee18659eca, content=临床药师更应该顿关注平时常用药物的安全使用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Tue Apr 11 08:05:01 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186476, encodeId=48e41864e6ea, content=谢谢分享。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Apr 10 21:36:43 CST 2017, time=2017-04-10, status=1, ipAttribution=)]
    2017-04-11 cqykthl

    临床药师更应该顿关注平时常用药物的安全使用。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1924933, encodeId=22cc19249337b, content=<a href='/topic/show?id=51d359969ac' target=_blank style='color:#2F92EE;'>#普通感冒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59969, encryptionId=51d359969ac, topicName=普通感冒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=754b42, createdName=Luyuxie_9, createdTime=Sun Jan 07 22:36:00 CST 2018, time=2018-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1968920, encodeId=c9e519689205e, content=<a href='/topic/show?id=13d010310690' target=_blank style='color:#2F92EE;'>#麻黄碱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103106, encryptionId=13d010310690, topicName=麻黄碱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=856b247, createdName=songbq, createdTime=Sat Feb 10 09:36:00 CST 2018, time=2018-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465535, encodeId=12ee146553524, content=<a href='/topic/show?id=144f5032688' target=_blank style='color:#2F92EE;'>#影响因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50326, encryptionId=144f5032688, topicName=影响因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80a06745918, createdName=chenzhuanggui, createdTime=Wed Apr 12 07:36:00 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186622, encodeId=500a18662257, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/d2ed7ec88067f7d4e256d4ab466d69b4/90f3cc295877498e263e9cdd0ae18ae8.jpg, createdBy=33ea1989011, createdName=dilshat910, createdTime=Tue Apr 11 10:00:16 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186597, encodeId=e9ee18659eca, content=临床药师更应该顿关注平时常用药物的安全使用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdicLmdJEK9VoiaDianY6fzHNN9iaGv80m39pMHU3eSnNN0kn1o0rdQ7Bz2f03Qibcf1ia7rKvxIt4UVlErF2d4gCmDC5/0, createdBy=98e31740255, createdName=cqykthl, createdTime=Tue Apr 11 08:05:01 CST 2017, time=2017-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186476, encodeId=48e41864e6ea, content=谢谢分享。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Apr 10 21:36:43 CST 2017, time=2017-04-10, status=1, ipAttribution=)]
    2017-04-10 doctorJiangchao

    谢谢分享。

    0

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