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Brit J Cancer:结肠癌中抑癌基因RHOA失活机制研究

2017-12-11 zhangfan MedSci原创

研究证实,结肠癌细胞通过遗传、转录和转录后机制下调抑癌基因RHOA的表达

RHOA信号抑制可增加结直肠肿瘤的生长-转移能力,但RHOA信号抑制在结肠癌发病过程中的机制尚不明确。

研究人员通过细胞模型表达并激活RHOA,考察RHOA的突变/缺失和启动子甲基化对RHOA功能的影响,通过WB以及qPCR 考察micRNA、 SMAD4以及c-MYC途径对RHOA表达的影响。

研究证实,RHOA点突变以及启动子高度甲基化不会影响结肠癌中RHOA基因的表达,但16%的结肠癌存在RHOA拷贝缺失,可导致RHOA表达减少。研究证实miR-200a/b/429可下调结肠癌中RHOA的表达,TGF-β/SMAD4可上调RHOA启动子。Wnt信号通路中的目标基因c-MYC,通过干扰SP1与RHOA启动子结合,导致结肠癌细胞中RHOA转录下调。

研究证实,结肠癌细胞通过遗传、转录和转录后机制下调抑癌基因RHOA的表达。

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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Dec 14 12:48:25 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269259, encodeId=9727269259d6, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Thu Dec 14 06:52:37 CST 2017, time=2017-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269088, encodeId=dece26908809, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-12-14 虈亣靌

    学习了谢谢作者分享!

    0

  5. 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    2017-12-14 1209e435m98(暂无昵称)

    学习了.谢谢分享!

    0

  6. 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    2017-12-13 半夏微凉

    学习了谢谢分享

    0

  7. 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  9. 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    2017-12-11 131****1460

    学习了受益匪浅

    0

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    2017-12-11 飛歌

    学习了很有用不错

    0

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