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地高辛中毒,易被忽视的“用药陷阱”!

2017-12-30 田兆兴 北京大学第三医院

电视剧《急诊科医生》中,一位略显肥胖的男性患者,虽然剧情不多,但却令人印象深刻!患者回答最多的两句话,不是“疼!”,就是“记不清了!”。

电视剧《急诊科医生》中,一位略显肥胖的男性患者,虽然剧情不多,但却令人印象深刻!患者回答最多的两句话,不是“疼!”,就是“记不清了!”。

这是一位腹痛的患者,意识淡漠,体态肥胖,全腹压痛,还伴有恶心呕吐等症状。

剧中,海洋医生接诊,感觉问题严重,请普外科专家吴仲恺主任会诊,因腹痛原因不明,且进行性加重,二位医生商量后,决定剖腹探查。

正在准备马上手术之际,幸遇何建一主任到场,经过细致检查,发现患者为地高辛中毒,并非急腹症,及时制止了一起手术悲剧!

故事跌宕起伏、扣人心弦,由全腹部压痛、反跳痛,怀疑急腹症决定手术,到急诊科主任及时到场,发现三度房室传导阻滞,推翻急腹症诊断!从推翻手术决定到患者内科药物治疗转危为安,情节可谓一波三折!

1.地高辛中毒到底是怎么回事?诊断有这么复杂吗?

看完电视剧后,大家不禁会问,地高辛中毒到底是怎么回事?诊断起来有这么复杂吗?笔者2007年也曾经遇到过一位患者,男性,70岁,半年前出现恶心呕吐症状,同时总觉得“暗无天日”,即使天气晴朗,他也觉得眼前都是昏沉沉的。

半年间,因为恶心呕吐症状愈来愈严重,他先后去过多家医院,找过多位专家,反复进行了多次全身系统检查,并且服用了多种胃肠道药物,但是,症状不但没有减轻,相反越来越重。

直到有一天,他恶心呕吐严重,来到三院急诊,当时接诊的刚好是我,询问老人家具体病史、症状。

“有没有什么基础疾病?

“没有!”

“有没有服用什么药物?”

“没有!”

老人强调最多的就是,恶心呕吐越来越重,吃什么药都不管用,并且不管多好的天气,总有“暗无天日”的感觉。

总觉得暗无天日,多家医院,多次全面检查均在正常范围,莫非老人家患了“抑郁”?沉思良久,我忽然眼前一亮。

直接问了一句:“您以前是不是患有心衰啊?”

这时老人家才说,“的确是患有心衰”,但同时又补充一句:“心衰一直在吃药,控制非常好!”

听了这个,我已经明白老人家得的是什么病了:“您是不是每天都在服用地高辛啊?”

老人家突然一愣,“是啊,已经连续服用了好几年了,每天一片,但每次到医院检查,大夫都说没有问题啊!”

为了确诊,老人抽血检查了地高辛浓度,30分钟后结果显示,血液中地高辛浓度是正常值的10倍,正是地高辛中毒。

经过有针对性治疗一周,老人恶心呕吐的症状完全消失,“暗无天日”的感觉也没有了那么,地高辛到底是一种什么药物?中毒后有何症状呢?

2.地高辛到底是一种什么药物?中毒后有何症状呢?

地高辛是中效强心苷类药物,是目前治疗心衰的经典用药,对心脏有正性肌力作用,能够减慢心率,抑制心脏传导,适用于低心输出量型充血性心力衰竭、心房颤动、心房扑动、阵发性室上性心动过速等等。地高辛排泄较快而且蓄积性较小,半衰期33~34 h,中毒血药浓度2.73~3.9 nmol/L,成人致死量10 mg。

地高辛中毒常见的症状主要有消化道反应,如厌食、恶心、呕吐、腹痛、腹泻等;视觉障碍,如黄视、绿视、视物模糊、畏光等;神经系统症状,如眩晕、头痛、失眠、嗜睡、精神错乱、癫痫样抽搐发作等;心脏反应,如室性早搏、阵发性室上性和室性心动过速、心房颤动及不同程度的房室传导阻滞,严重者可发生心室纤颤,心搏骤停、猝死。

从《急诊科医生》和三院接诊的这两位患者的情况来看,我们能够发现,一位患者患有阿尔茨海默病,也就是早老性痴呆,另一位则是年龄较高的老年人。在看病时,他们常常不能将自己的病史和用药情况说明白,这是影响确诊的重要原因。

患者只能描述说“疼”,“记不清了”!即便医生问到既往患有什么疾病时,也会说自己没啥毛病,问他平时正在服用什么药物时,他可能仍然说没有。

但是,经过有针对性的询问,他说自己患心衰多年,一直吃药控制很好,服用地高辛,每天一片。在老人看来,吃地高辛就如同平时吃饭一样,所以在问他平时是否服用什么药物的时候,他就略过了这条重要线索,因此也就瞒过了众多的医生。

临床中还有很多内科疾病可能会表现为急腹症,如糖尿病酮症酸中毒、腹型过敏性紫癜、血卟啉病、铅汞中毒、急性心肌梗死、系统性红斑狼疮、腹型上呼吸道感染、急性白血病、伤寒等等。因此,不单单是地高辛中毒是临床医生的易入的陷阱,其他内科疾病稍有不慎也容易蒙蔽我们的双眼。

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    2018-01-10 wzb521zf

    一起学习学习

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    2017-12-31 mashirong
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  4. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Dec 30 08:32:49 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273760, encodeId=3f602e3760ad, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sat Dec 30 07:33:02 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273755, encodeId=7d142e3755ae, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sat Dec 30 07:26:50 CST 2017, time=2017-12-30, status=1, ipAttribution=)]
    2017-12-31 137****9095

    henhao

    0

  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Dec 30 08:32:49 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273760, encodeId=3f602e3760ad, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sat Dec 30 07:33:02 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273755, encodeId=7d142e3755ae, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sat Dec 30 07:26:50 CST 2017, time=2017-12-30, status=1, ipAttribution=)]
    2017-12-30 thlabcde

    好资料学习了!

    0

  6. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Sat Dec 30 09:53:54 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273813, encodeId=0ad72e381333, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sat Dec 30 09:45:20 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273775, encodeId=92812e377556, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Dec 30 08:32:49 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273760, encodeId=3f602e3760ad, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sat Dec 30 07:33:02 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273755, encodeId=7d142e3755ae, content=谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sat Dec 30 07:26:50 CST 2017, time=2017-12-30, status=1, ipAttribution=)]
    2017-12-30 衣带渐宽

    学习

    0

  7. 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channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sat Dec 30 07:26:50 CST 2017, time=2017-12-30, status=1, ipAttribution=)]
    2017-12-30 明月清辉

    谢谢分享.学习了

    0

  8. 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channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Sat Dec 30 07:26:50 CST 2017, time=2017-12-30, status=1, ipAttribution=)]
    2017-12-30 Y—xianghai

    学习了新知识

    0

  9. 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    2017-12-30 wzb521zf

    一起学习学习

    0

  10. 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    2017-12-30 榄枷檬

    谢谢分享

    0

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