Baidu
map

进展

订阅

MedSci主页 / 所有栏目 / 进展

Sci Rep：基于干细胞介导的骨生成快速形成矿化骨组织的仿生基质

2018-10-04 MedSci MedSci原创

关注

骨折后的骨再生依赖于自体和同种异体骨移植。然而，大多数骨折群体是骨质量差的老年人，伴随着对骨形成和矿化至关重要的基质蛋白的损失和/或改变。同种异体移植物受到相同的限制并且具有延迟愈合、感染、免疫排斥和最终骨折的风险。在这项工作中，我们应用协同仿生策略来开发快速形成骨组织的基质，这是承重骨骼骨折愈合的一个关键方面。使用两种关键基质蛋白——骨钙蛋白（OC）和/或骨桥蛋白（OPN）增强的胶原基质，通过增

骨折后的骨再生依赖于自体和同种异体骨移植。然而，大多数骨折群体是骨质量差的老年人，伴随着对骨形成和矿化至关重要的基质蛋白的损失和/或改变。同种异体移植物受到相同的限制并且具有延迟愈合、感染、免疫排斥和最终骨折的风险。

在这项工作中，我们应用协同仿生策略来开发快速形成骨组织的基质，这是承重骨骼骨折愈合的一个关键方面。使用两种关键基质蛋白——骨钙蛋白（OC）和/或骨桥蛋白（OPN）增强的胶原基质，通过增加间充质干/基质细胞（MSC）增殖，加速成骨分化，增强血管生成来增加合成骨基质的速率和数量。从各种人体组织来源（骨髓，脂肪和脐带）获得的MSCs持续的骨形成反应。在临界尺寸缺陷兔长骨模型中OC/OPN矿化支架的体内评估未显示骨组织形成时的任何异物反应。

我们展示了一种新的仿生策略，可快速形成矿化骨组织，并通过多种来源的MSCs确保持续的骨形成反应，从而有助于更快的患者恢复和治疗衰老和患病人群中的非愈合骨折。无细胞仿生基质从MSCs获得骨再生反应，从多种组织来源获得，可以用于各种支架，且其获取广泛。

原始出处：

Marta S. Carvalho, Atharva A. Poundarik, et al.,感染、免疫排斥和最终骨折的风险。 在这项工作中，我们应用协同仿生策略来开发快速形成骨组织的基质，这是承重骨骼骨折愈合的一个关键方面。使用两种关键基质蛋白——骨钙蛋白（OC）和/或骨桥蛋白（OPN）增强的胶原基质，通过增加间充质干/基质细胞（MSC）增殖，加速成骨分化，增强血管生成来增加合成骨基质的速率和数量。从各种人体组织来源（骨髓，脂肪和脐带）获得的MSCs持续的骨形成反应。在临界尺寸缺陷兔长骨模型中OC/OPN矿化支架的体内评估未显示骨组织形成时的任何异物反应。 我们展示了一种新的仿生策略，可快速形成矿化骨组织，并通过多种来源的MSCs确保持续的骨形成反应，从而有助于更快的患者恢复和治疗衰老和患病人群中的非愈合骨折。无细胞仿生基质从MSCs获得骨再生反应，从多种组织来源获得，可以用于各种支架，且其获取广泛。 原始出处： Marta S. Carvalho, Atharva A. Poundarik, et al., Biomimetic matrices for rapidly forming mineralized bone tissue based on stem cell-mediated osteogenesis. Sci Rep. 2018; 8: 14388." target="_blank"> Biomimetic matrices for rapidly forming mineralized bone tissue based on stem cell-mediated osteogenesis. Sci Rep. 2018; 8: 14388.


版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1757123, encodeId=8e2d1e5712380, content=<a href='/topic/show?id=103b421e0e8' target=_blank style='color:#2F92EE;'>#基质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42170, encryptionId=103b421e0e8, topicName=基质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=281337296540, createdName=ms7899726347904398, createdTime=Tue May 14 17:24:00 CST 2019, time=2019-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721317, encodeId=2e221e21317b0, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Fri Apr 19 03:24:00 CST 2019, time=2019-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076342, encodeId=854e20e6342aa, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Sat Jan 19 13:24:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348145, encodeId=ae2d348145bd, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Sat Oct 06 07:09:26 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347968, encodeId=783734e968b7, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Oct 05 07:13:13 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347960, encodeId=ac9534e9601e, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Fri Oct 05 06:50:12 CST 2018, time=2018-10-05, status=1, ipAttribution=)]
    2019-05-14 ms7899726347904398

    #基质#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1757123, encodeId=8e2d1e5712380, content=<a href='/topic/show?id=103b421e0e8' target=_blank style='color:#2F92EE;'>#基质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42170, encryptionId=103b421e0e8, topicName=基质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=281337296540, createdName=ms7899726347904398, createdTime=Tue May 14 17:24:00 CST 2019, time=2019-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721317, encodeId=2e221e21317b0, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Fri Apr 19 03:24:00 CST 2019, time=2019-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076342, encodeId=854e20e6342aa, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Sat Jan 19 13:24:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348145, encodeId=ae2d348145bd, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Sat Oct 06 07:09:26 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347968, encodeId=783734e968b7, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Oct 05 07:13:13 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347960, encodeId=ac9534e9601e, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Fri Oct 05 06:50:12 CST 2018, time=2018-10-05, status=1, ipAttribution=)]
    2019-04-19 yahu

    #矿化#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1757123, encodeId=8e2d1e5712380, content=<a href='/topic/show?id=103b421e0e8' target=_blank style='color:#2F92EE;'>#基质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42170, encryptionId=103b421e0e8, topicName=基质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=281337296540, createdName=ms7899726347904398, createdTime=Tue May 14 17:24:00 CST 2019, time=2019-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721317, encodeId=2e221e21317b0, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Fri Apr 19 03:24:00 CST 2019, time=2019-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076342, encodeId=854e20e6342aa, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Sat Jan 19 13:24:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348145, encodeId=ae2d348145bd, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Sat Oct 06 07:09:26 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347968, encodeId=783734e968b7, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Oct 05 07:13:13 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347960, encodeId=ac9534e9601e, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Fri Oct 05 06:50:12 CST 2018, time=2018-10-05, status=1, ipAttribution=)]
    2019-01-19 diushouji

    #骨组织#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1757123, encodeId=8e2d1e5712380, content=<a href='/topic/show?id=103b421e0e8' target=_blank style='color:#2F92EE;'>#基质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42170, encryptionId=103b421e0e8, topicName=基质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=281337296540, createdName=ms7899726347904398, createdTime=Tue May 14 17:24:00 CST 2019, time=2019-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721317, encodeId=2e221e21317b0, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Fri Apr 19 03:24:00 CST 2019, time=2019-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076342, encodeId=854e20e6342aa, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Sat Jan 19 13:24:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348145, encodeId=ae2d348145bd, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Sat Oct 06 07:09:26 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347968, encodeId=783734e968b7, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Oct 05 07:13:13 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347960, encodeId=ac9534e9601e, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Fri Oct 05 06:50:12 CST 2018, time=2018-10-05, status=1, ipAttribution=)]
    2018-10-06 1e1c07bdm01(暂无匿称)

    好

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1757123, encodeId=8e2d1e5712380, content=<a href='/topic/show?id=103b421e0e8' target=_blank style='color:#2F92EE;'>#基质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42170, encryptionId=103b421e0e8, topicName=基质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=281337296540, createdName=ms7899726347904398, createdTime=Tue May 14 17:24:00 CST 2019, time=2019-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721317, encodeId=2e221e21317b0, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Fri Apr 19 03:24:00 CST 2019, time=2019-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076342, encodeId=854e20e6342aa, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Sat Jan 19 13:24:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348145, encodeId=ae2d348145bd, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Sat Oct 06 07:09:26 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347968, encodeId=783734e968b7, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Oct 05 07:13:13 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347960, encodeId=ac9534e9601e, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Fri Oct 05 06:50:12 CST 2018, time=2018-10-05, status=1, ipAttribution=)]
    2018-10-05 明月清辉

    谢谢分享，学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1757123, encodeId=8e2d1e5712380, content=<a href='/topic/show?id=103b421e0e8' target=_blank style='color:#2F92EE;'>#基质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42170, encryptionId=103b421e0e8, topicName=基质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=281337296540, createdName=ms7899726347904398, createdTime=Tue May 14 17:24:00 CST 2019, time=2019-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1721317, encodeId=2e221e21317b0, content=<a href='/topic/show?id=0143e3298c3' target=_blank style='color:#2F92EE;'>#矿化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73298, encryptionId=0143e3298c3, topicName=矿化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a5532986439, createdName=yahu, createdTime=Fri Apr 19 03:24:00 CST 2019, time=2019-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076342, encodeId=854e20e6342aa, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Sat Jan 19 13:24:00 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348145, encodeId=ae2d348145bd, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d551998554, createdName=1e1c07bdm01(暂无匿称), createdTime=Sat Oct 06 07:09:26 CST 2018, time=2018-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347968, encodeId=783734e968b7, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Oct 05 07:13:13 CST 2018, time=2018-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347960, encodeId=ac9534e9601e, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Fri Oct 05 06:50:12 CST 2018, time=2018-10-05, status=1, ipAttribution=)]
    2018-10-05 深海的鱼

    学习学习学习

    0

Baidu
map
Baidu
map
Baidu
map