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Materials:MBG涂覆可有效增强Ti-6Al-4V支架材料的表面生物活性

2018-01-20 MedSci MedSci原创

通过选择性激光熔融(SLM)制造的多孔Ti-6Al-4V支架,其形状可控、机械性能优良,已经发展成为一类具有很好的骨修复潜力的生物材料。然而,Ti-6Al-4V合金作为支架基质因其生物惰性而缺乏刺激骨向内生长和再生的能力。本研究旨在通过在SLM Ti-6Al-4V支架上开发生物活性涂层以增加所需的表面成骨能力。通过旋涂将介孔生物活性玻璃(MBGs)涂层施加在SLM Ti-6Al-4V支架的支柱表面

通过选择性激光熔融(SLM)制造的多孔Ti-6Al-4V支架,其形状可控、机械性能优良,已经发展成为一类具有很好的骨修复潜力的生物材料。然而,Ti-6Al-4V合金作为支架基质因其生物惰性而缺乏刺激骨向内生长和再生的能力。

本研究旨在通过在SLM Ti-6Al-4V支架上开发生物活性涂层以增加所需的表面成骨能力。通过旋涂将介孔生物活性玻璃(MBGs)涂层施加在SLM Ti-6Al-4V支架的支柱表面上,随后进行热处理。

结果显示,涂层能够保持MBG的特征介孔结构和化学组成,并且与Ti-6Al-4V基底建立良好的界面粘附。支架的抗压强度和孔连通性不受涂层的影响。此外,体外细胞培养实验结果表明,与常规生物活性玻璃(BG)涂覆的Ti-6Al-4V支架和裸金属Ti-6Al-4V支架相比,人类骨髓基质细胞(hBMSCs)在MBG包被的Ti-6Al-4V支架上的附着、增殖和分化得到改善。

综上所述,该研究结果表明,通过使用旋涂法将MBG涂覆在SLM Ti-6Al-4V支架表面可有效增强支架表面生物功能化能力。

原始出处:

Ye X, Leeflang S, et al., Mesoporous Bioactive Glass Functionalized 3D Ti-6Al-4V Scaffolds with Improved Surface Bioactivity. Materials (Basel). 2017 Oct 27;10(11). pii: E1244. doi: 10.3390/ma10111244.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1775799, encodeId=53561e757997b, content=<a href='/topic/show?id=a7235e107b2' target=_blank style='color:#2F92EE;'>#支架材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57107, encryptionId=a7235e107b2, topicName=支架材料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce4f38811844, createdName=tidiq, createdTime=Sat Jun 30 20:38:00 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280348, encodeId=eb242803486d, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=7dcf1938111, createdName=1e0e5a1fm42(暂无匿称), createdTime=Sat Jan 20 14:03:12 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280337, encodeId=686a28033ea3, content=看看了解一下.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sat Jan 20 13:45:07 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1775799, encodeId=53561e757997b, content=<a href='/topic/show?id=a7235e107b2' target=_blank style='color:#2F92EE;'>#支架材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57107, encryptionId=a7235e107b2, topicName=支架材料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce4f38811844, createdName=tidiq, createdTime=Sat Jun 30 20:38:00 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280348, encodeId=eb242803486d, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=7dcf1938111, createdName=1e0e5a1fm42(暂无匿称), createdTime=Sat Jan 20 14:03:12 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280337, encodeId=686a28033ea3, content=看看了解一下.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sat Jan 20 13:45:07 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
    2018-01-20 1e0e5a1fm42(暂无匿称)

    henhao

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1775799, encodeId=53561e757997b, content=<a href='/topic/show?id=a7235e107b2' target=_blank style='color:#2F92EE;'>#支架材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57107, encryptionId=a7235e107b2, topicName=支架材料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce4f38811844, createdName=tidiq, createdTime=Sat Jun 30 20:38:00 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280348, encodeId=eb242803486d, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=7dcf1938111, createdName=1e0e5a1fm42(暂无匿称), createdTime=Sat Jan 20 14:03:12 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280337, encodeId=686a28033ea3, content=看看了解一下.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sat Jan 20 13:45:07 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
    2018-01-20 xiaotaiyang1

    看看了解一下.谢谢分享

    0

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