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SCI REP:HOTAIR rs7958904多态性与中国人口中子宫颈癌风险增加有关

2017-06-10 MedSci MedSci原创

在之前的研究中,我们已经确定了长非编码RNA HOX转录本的反义RNA(HOTAIR)中的单核苷酸多态性(SNP)rs7958904和rs4759314分别与结肠直肠癌和胃癌的风险显着相关。因此,在这项研究中,我们旨在调查HOTAIR SNP与宫颈癌(CC)易感性之间的关联。

在之前的研究中,我们已经确定了长非编码RNA HOX转录本的反义RNA(HOTAIR)中的单核苷酸多态性(SNP)rs7958904和rs4759314分别与结肠直肠癌和胃癌的风险显着相关。因此,在这项研究中,我们旨在调查HOTAIR SNP与宫颈癌(CC)易感性之间的关联。本研究对1209例实验组和1348例对照组进行关联研究,并用TaqMan等位基因分型法进行基因分型。利用癌基因组图谱(TCGA)数据库对等位基因特异性HOTAIR表达进行体内分析。MTT测定用于评估等位基因特异性细胞增殖。与GG / GC基因型相比,rs7958904 CC基因型与宫颈癌风险增加有关(OR = 1.57,95%CI = 1.10-2.25)。TCGA数据库的数据显示rs7958904 CC基因型的CC组织具有比GG基因型更高的HOTAIR表达(P = 0.046)。MTT测定显示rs7958904 C等位基因对CC细胞的生长促进作用。当然,也需要进一步研究rs7958904对CC细胞生物学行为的影响,以证实和扩展我们的发现。总之,HOT AIR rs7958904可能通过调节CC细胞增殖来影响CC易感性,并因此可作为诊断生物标志物。

原文出处:

Hua Jin, Xiaoyun Lu,Shizhi Wang,et al.HOTAIR rs7958904 polymorphism is associated with increased cervical cancer risk in a Chinese population.[J]2017 June 9.doi:10.1038/s41598-017-03174-1

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    2017-09-09 sjq027
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    2018-03-21 weihongyv
  5. [GetPortalCommentsPageByObjectIdResponse(id=2061629, encodeId=e183206162991, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Sep 09 21:42:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069714, encodeId=b63c2069e1409, content=<a href='/topic/show?id=045f4631511' target=_blank style='color:#2F92EE;'>#宫颈癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46315, encryptionId=045f4631511, topicName=宫颈癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Thu Sep 07 17:42:00 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006687, encodeId=60a9200668e29, content=<a href='/topic/show?id=199d452095f' target=_blank style='color:#2F92EE;'>#子宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45209, encryptionId=199d452095f, topicName=子宫颈)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKjqGDO7icVKUiaT7urgwXvnvzWtp0fMFU46Xfib8oavFKygiaWtibXReS6ZUh3PImsNicGAwTO5HXxoicnA/132, createdBy=ee262500130, createdName=ms7474195563676018, createdTime=Thu Jun 29 20:42:00 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036508, encodeId=be75203650889, content=<a href='/topic/show?id=66c9904117' target=_blank style='color:#2F92EE;'>#HOTAIR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9041, encryptionId=66c9904117, topicName=HOTAIR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Wed Mar 21 18:42:00 CST 2018, time=2018-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282860, encodeId=7520128286096, content=<a href='/topic/show?id=53f24521227' target=_blank style='color:#2F92EE;'>#子宫颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45212, encryptionId=53f24521227, topicName=子宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6411176, createdName=mfx799, createdTime=Mon Jun 12 09:42:00 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408035, encodeId=ba2d140803539, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Mon Jun 12 09:42:00 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629215, encodeId=c314162921592, content=<a href='/topic/show?id=0c1c4325170' target=_blank style='color:#2F92EE;'>#多态性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43251, encryptionId=0c1c4325170, topicName=多态性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d83c21331263, createdName=xzw120, createdTime=Mon Jun 12 09:42:00 CST 2017, time=2017-06-12, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2061629, encodeId=e183206162991, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Sep 09 21:42:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069714, encodeId=b63c2069e1409, content=<a href='/topic/show?id=045f4631511' target=_blank style='color:#2F92EE;'>#宫颈癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46315, encryptionId=045f4631511, topicName=宫颈癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Thu Sep 07 17:42:00 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006687, encodeId=60a9200668e29, content=<a href='/topic/show?id=199d452095f' target=_blank style='color:#2F92EE;'>#子宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45209, encryptionId=199d452095f, topicName=子宫颈)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKjqGDO7icVKUiaT7urgwXvnvzWtp0fMFU46Xfib8oavFKygiaWtibXReS6ZUh3PImsNicGAwTO5HXxoicnA/132, createdBy=ee262500130, createdName=ms7474195563676018, createdTime=Thu Jun 29 20:42:00 CST 2017, time=2017-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036508, encodeId=be75203650889, content=<a href='/topic/show?id=66c9904117' target=_blank style='color:#2F92EE;'>#HOTAIR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9041, encryptionId=66c9904117, topicName=HOTAIR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Wed Mar 21 18:42:00 CST 2018, time=2018-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282860, encodeId=7520128286096, content=<a href='/topic/show?id=53f24521227' target=_blank style='color:#2F92EE;'>#子宫颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45212, encryptionId=53f24521227, topicName=子宫颈癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6411176, createdName=mfx799, createdTime=Mon Jun 12 09:42:00 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1408035, encodeId=ba2d140803539, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Mon Jun 12 09:42:00 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629215, encodeId=c314162921592, content=<a href='/topic/show?id=0c1c4325170' target=_blank style='color:#2F92EE;'>#多态性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43251, encryptionId=0c1c4325170, topicName=多态性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d83c21331263, createdName=xzw120, createdTime=Mon Jun 12 09:42:00 CST 2017, time=2017-06-12, status=1, ipAttribution=)]
    2017-06-12 一闲
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    2017-06-12 xzw120

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