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Ann Thorac Surg:上海胸科医院方文涛等发现胸腺鳞状细胞癌完全切除可使患者获益

2013-09-06 萧弈 DXY

胸腺鳞状细胞癌是罕见的恶性肿瘤,其外科治疗效果相关报道较少,临床和病理特点及影响预后的因素目前为止尚不确定。为此,来自中国上海胸科医院胸外科的方文涛教授等人进行了一项研究,研究结果在线发表于2013年7月15日的《胸外科年鉴》(Ann Thorac Surg)杂志上。研究发现,完全切除胸腺鳞状细胞癌可以预测更好的整体生存率,同时可延长术后无病生存时间。该研究纳入了2003年2月至2010年12月间

胸腺鳞状细胞癌是罕见的恶性肿瘤,其外科治疗效果相关报道较少,临床和病理特点及影响预后的因素目前为止尚不确定。为此,来自中国上海胸科医院胸外科的方文涛教授等人进行了一项研究,研究结果在线发表于2013年7月15日的《胸外科年鉴》(Ann Thorac Surg)杂志上。研究发现,完全切除胸腺鳞状细胞癌可以预测更好的整体生存率,同时可延长术后无病生存时间。
该研究纳入了2003年2月至2010年12月间在上海胸科医院进行手术治疗的105例患者,均经病理证实为胸腺鳞状细胞癌,回顾性分析其临床和病理资料。研究采用Kaplan-Meier和log rank检验进行生存分析,使用Cox回归模型进行多因素分析。【原文下载

研究结果发现,鳞状细胞亚型占胸腺癌的73.4%和胸腺肿瘤的16.1%。受试者5年总生存率和无病生存率分别为59.5%和57.6%。多变量分析中,只有完全切除(危险比3.692)对整体生存有显着影响。完全切除(危险比2.361)和化疗(危险比0.307)与无病生存率相关。

该研究结果表明,完全切除不仅可以预测胸腺鳞状细胞癌更好的整体生存率,还能够延长患者术后无病生存时间。该研究为特定的胸腺癌临床分期提供了更多证据。同时作者认为,Masaoka-Koga分期可能不是胸腺癌的独立预后因素。

原文下载

Zhao Y, Zhao H, Hu D, Fan L, Shi J, Fang W.Surgical treatment and prognosis of thymic squamous cell carcinoma: a retrospective analysis of 105 cases.Ann Thorac Surg. 2013 Sep;96(3):1019-24.

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