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NEJM:痛风未经治疗后会怎么样?

2022-02-07 Shirley MedSci原创

一则未经降尿酸治疗后,患者关节炎持续恶化的案例。

一名患有痛风和慢性肾病的 65 岁男性因 5 年的手、脚和膝盖关节疼痛和肿胀而到皮肤科就诊。在这 5 年中,他间歇性地接受了痛风药物治疗,并有相关的短暂改善期;然而,他并没有持续接受长期药物治疗,而且他的关节炎不断恶化。

在体格检查中,他的手(图 A)、脚和膝关节有多个痛风石和畸形。他被转诊到风湿病诊所进行进一步评估和治疗。实验室研究显示血清尿酸水平为 9.6 mg/dL(570 μmol/L;参考范围,3.5 至 7.0 mg/dL [210 至 420 μmol/L])和血清肌酐水平为 1.8 mg/dL(160 μmol/L升;参考范围,0.7 至 1.2 mg/dL [60 至 110 μmol/L])。

右脚第一跖趾关节的关节穿刺术产生了粘稠的白色渗出液;在偏光显微镜下可见许多单钠尿酸盐晶体(图 B)。开始降尿酸治疗。随访10个月,患者关节疼痛和肿胀明显减轻。

文章来源:N Engl J Med 2021;385:e97  DOI: 10.1056/NEJMicm2112548

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    2022-03-27 swj851016

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    2022-02-17 huitailang

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    2022-02-13 ms5000000518166734

    学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习学习

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    2022-02-10 陈宪

    规范诊疗最重要

    0

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    2022-02-08 查查佳佳

    2022临床大数据分析系列课程报名表

    0

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