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Clinica Chimica Acta:血清nardilysin水平在预测成人恶性脑梗死患者30天死亡率中的临床意义

2019-09-13 gladiator MedSci原创

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Nardilysin是一种金属内肽酶,在多种炎症性疾病中发挥重要作用。恶性脑梗死(Glasgow coma scale score <9)与高死亡率风险相关。在此,本研究拟探讨血清纳地平水平与恶性脑梗死患者预后的关系。

在研究开始时,研究人员对105例恶性脑梗死患者和105例健康对照者血清nardilysin浓度进行了定量。用多变量分析估计nardilysin浓度与30天死亡率和总生存率的关系。

研究发现,与对照组相比,患者的血清nardilysin浓度明显升高。Nardilysin浓度与格拉斯哥昏迷评分和血清c反应蛋白浓度呈显著相关。血清nardilysin可独立预测30天死亡率和总生存率。在接收者工作特性曲线下,发现其具有较高的分辨能力。

脑梗死后血清nardilysin浓度升高与脑卒中严重程度、炎症程度和较高的死亡风险密切相关,本研究证实血清nardilysin是恶性脑梗死的一种潜在的预后生物标志物。

原始出处:

Fang-Hui ChenYi WangClinical determination of serum nardilysin levels in predicting 30-day mortality among adults with malignant cerebral infarction

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    2020-08-16 windight
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    2019-09-15 karmond
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