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Gastroenterology:低FODMAP饮食与IBD患者症状缓解

2019-10-06 MedSci MedSci原创

低可发酵低聚糖、双糖、单糖和多元醇饮食可改善静止期肠易激综合征患者特异性症状评分

有限的证据表明低可发酵低聚糖、双糖、单糖和多元醇(FODMAPs)可以减轻静止期炎症性肠病(IBD)患者的肠道症状。近日研究人员开展随机对照研究,考察低FODMAP饮食对静止期IBD患者持续肠道症状,肠道微生物群,循环标志炎症的影响。


52名静止期CD或UC患者参与研究,随机接受低FODMAP饮食(n=27)或对照(n=25),持续4周。采用问卷的形式评估参与者肠道症状和与健康相关的生活质量。在基线和试验结束时采集粪便和血样,对粪便微生物组分组成和功能进行了分析,并对其进行了亚基因组测序和T细胞表型分析。


低FODMAP组有较高比例的患者报告肠道症状得到充分缓解(14/27, 52%),而安慰剂组缓解比例较少(4/25, 16%)。低FODMAP组肠易激综合征严重程度评分减少较多(平均减少67 vs 安慰剂组34),但不显著,健康相关的生活质量得分较高(81.9 vs 78.3)。低FODMAP组粪便青春双歧杆菌、B长杆菌和粪肠杆菌的丰度高于安慰剂,但组间微生物多样性和炎症标志物无显著性差异。


研究发现,低可发酵低聚糖、双糖、单糖和多元醇饮食可改善静止期肠易激综合征患者特异性症状评分。


原始出处:


Selina R. Cox et al. Effects of Low-FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial.Gastroenterology. October 2019.


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    2020-02-19 许安
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    2019-10-08 bnurmamat
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