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NEJM:肠内喂养与早产儿神经发育障碍

2019-10-10 MedSci MedSci原创

早产儿或极低出生体重儿肠内喂养量增加速度与神经发育障碍无显著相关性

观察研究数据显示,早产儿肠内喂养量增加速度与坏死性小肠结肠炎与迟发性脓毒症的风险相关。近日研究人员就肠内喂养量增加速度与神经发育不良之间的关系进行了研究。

极早产儿或极低出生体重儿参与研究,随机每天奶增量30毫升每公斤体重(快速增加组)或18毫升每公斤(缓慢增加组)。研究的主要终点为24个月无中度或重度神经发育障碍情况下存活。次要结果包括证实或怀疑迟发性脓毒症,坏死性小肠结肠炎和脑瘫。

1224名早产儿分配至快速增加组,1246名早产儿分配至缓慢增加组。802名快速增加组以及848名缓慢增加组早产儿达到主要终点(65.5 vs 68.1%,rr=0.96)。414名快速增加组以及434名缓慢增加组早产儿发生迟发脓毒症(29.8 vs 31.1%,rr=0.96),70名快速增加组以及78名缓慢增加组早产儿发生坏死性小肠结肠炎(5.0 vs 5.6%,rr=0.88)。

研究认为,早产儿或极低出生体重儿肠内喂养量增加速度与神经发育障碍无显著相关性。

原始出处:

Jon Dorling et al. Controlled Trial of Two Incremental Milk-Feeding Rates in Preterm Infants. N Engl J Med, October 10, 2019.

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    2019-10-12 neurowu
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1665087, encodeId=6a38166508e19, content=<a href='/topic/show?id=c8664008e1a' target=_blank style='color:#2F92EE;'>#喂养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40087, encryptionId=c8664008e1a, topicName=喂养)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0ed425881542, createdName=ms1948154235210413, createdTime=Wed Aug 19 07:41:00 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2060818, encodeId=e2352060818c9, content=<a href='/topic/show?id=c73f3e96355' target=_blank style='color:#2F92EE;'>#发育障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37963, encryptionId=c73f3e96355, topicName=发育障碍)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Sun Mar 15 21:41:00 CST 2020, time=2020-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345623, encodeId=aeef1345623f3, content=<a href='/topic/show?id=37c9e4238b9' target=_blank style='color:#2F92EE;'>#神经发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74238, encryptionId=37c9e4238b9, topicName=神经发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Sat Oct 12 09:41:00 CST 2019, time=2019-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347435, encodeId=9c32134e435b5, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Sat Oct 12 09:41:00 CST 2019, time=2019-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1506417, encodeId=f95c150641ed8, content=<a href='/topic/show?id=5ecce424448' target=_blank style='color:#2F92EE;'>#神经发育障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74244, encryptionId=5ecce424448, topicName=神经发育障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=69ca9750324, createdName=fzwish20003, createdTime=Sat Oct 12 09:41:00 CST 2019, time=2019-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1034978, encodeId=18d710349e882, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Oct 10 21:41:00 CST 2019, time=2019-10-10, status=1, ipAttribution=)]
    2019-10-10 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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