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Int J Audiol:听力损失与老年人海马萎缩和高皮质醇/脱氢表雄酮硫酸盐比值有关

2020-11-07 AlexYang MedSci原创

听力损失(HL)是年龄老化时认知障碍的一种前驱症状。目前仍不确定听力损失是否直接或间接导致认知障碍。

听力损失(HL)是年龄老化时认知障碍的一种前驱症状。目前仍不确定听力损失是否直接或间接导致认知障碍。

最近,有研究人员对参与者进行了听觉测试、血液检查和脑MRI检查。使用基于体素的特定区域计算海马(HP)的萎缩率。在控制年龄影响的同时进行了部分相关性分析,即分析影响听力水平和HP萎缩率(HP%)的因素。研究包括了36名有听力障碍的老年人。研究发现,中度或重度HL参与者(n=22)比轻度HL或听力正常组(n=14,p<0.05)具有有更高的皮质醇/脱氢表雄酮硫酸盐(C/D)比值、老年抑郁评分(GDS)和HP%。HP%与C/D比值、GDS和高频(HF)听力水平呈显著正相关(P<0.05)。C/D比与HP%和HF听力水平呈正相关(p<0.05)。

老年人中与听力损失相关的因素

最后,研究人员指出,HL与老年人的HP萎缩和高C/D比值有关;然而,HL可能与海马萎缩没有因果关系。

原始出处:

Mitsuhiro Aoki , Hiroshi Okuda, Hiromasa Ishihara et al. Hearing loss is associated with hippocampal atrophy and high cortisol/dehydroepiandrosterone sulphate ratio in older adults. Int J Audiol. Oct 2020

 

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    2021-04-13 chendoc252
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    2020-11-12 ms3000000449926787

    学习了

    0

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    2020-11-09 ysjykql

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