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Clinica Chimica Acta:外伤性脑损伤后血清组织激肽水平的测定

2019-12-21 MedSci MedSci原创

组织激肽在激肽系统中起着重要的作用。研究已经证明,它在创伤性脑损伤<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;; mso-fareast-font-family:宋体;mso-bidi-font-

组织激肽在激肽系统中起着重要的作用。研究已经证明,它在创伤性脑损伤(TBI)的保护作用。本研究试图确定TBI患者血清TK水平与创伤严重程度以及临床结果之间的关系。

研究人员招募了112名严重创伤性脑损伤的患者(格拉斯哥昏迷评分分数 <9)以及112名对照。通过建立2个多变量模型来评估血清TK水平与30天死亡之间的关系,分析其在受试者工作特性曲线下的预后预测能力。

研究结果显示,病人TK水平显著低于比对照组(中位数0.148mg / l,,下四分位数0.121 - -0.185与中位数0.258mg / l,,下四分位数0.207 - -0.342,P<0.001)TK含量与格拉斯哥昏迷评分分数密切和呈正相关(r=0.550)TK含量< 0.148mg / l独立预测30天死亡率价值优势比为4.752(95%可信区间(CI), 1.166 - -19.367)30天的总体生存价值风险比为3.698 (95% CI, 1.026 - -13.333)TK水平对30天死亡率有显著性差异,其曲线下面积为0.822 (95% CI, 0.738-0.887)

因此,不研究结果表明,血清TK可作为TBI患者临床预后的一个潜在预测指标。

原始出处:

Jian-Jun HuangShen-Zhong QiuDetermination of serum tissue kallikrein levels after traumatic brain injury

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2020-02-18 丁鹏鹏
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    2020-04-15 windight
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