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BMJ:饮食中总的、动物和植物蛋白质摄入量与全因、心血管疾病和癌症死亡之间的风险

2020-07-23 MedSci原创 MedSci原创

较高的总蛋白摄入量与较低的全因死亡风险有关,而植物蛋白的摄入量则可以降低全因和心血管疾病的死亡率。用植物蛋白源代替动物蛋白含量高的食物可能会延长寿命。

近日,顶级杂志BMJ上发表了一篇研究文章,该研究旨在评估和量化摄入总的、动物和植物蛋白与全因、血管疾病和癌症导致的死亡风险之间的潜在剂量反应关系。

研究人员对前瞻性队列研究进行了系统评价和荟萃分析。截至2019年12月,研究人员检索了PubMed、Scopus和ISI Web of Science以及检索到的相关文章的参考文献,并选择报告了18岁以上成年人全因、心血管疾病和癌症死亡率风险估计的前瞻性队列研究。随机效应模型用于计算最高和最低蛋白质摄入量的合并效应量和95%置信区间,并纳入研究之间的差异。研究人员进行了线性和非线性剂量反应分析,以评估蛋白质摄入量与死亡率之间的剂量反应关系。

32项前瞻性队列研究被纳入系统评价,31项研究被纳入荟萃分析。在3.5至32年的随访期间,715128名参与者中有113039人死亡(心血管疾病16429例,癌症22303例)。摄入总蛋白与较低的全因死亡风险相关(合并效应量为0.94,95%置信区间为0.89至0.99,I2=58.4%,P<0.001)。摄入植物蛋白与降低全因死亡率(合并效应大小为0.92、95%置信区间为0.87至0.97,I2=57.5%,P=0.003)和心血管疾病死亡率(合并风险比为0.88、95%置信区间为0.80至0.96,I2=63.7%,P=0.001)显著相关,但与癌症死亡率无关。摄入总蛋白和动物蛋白与心血管疾病和癌症死亡率的风险没有显著相关性。剂量反应分析显示,摄入植物蛋白与全因死亡率之间存在显著的剂量反应负相关(非线性,P=0.05)。每天从植物蛋白中获取3%的额外能量可使全因死亡风险降低5%。

由此可见,较高的总蛋白摄入量与较低的全因死亡风险有关,而植物蛋白的摄入量则可以降低全因和心血管疾病的死亡率。用植物蛋白源代替动物蛋白含量高的食物可能会延长寿命。

原始出处:

Sina Naghshi,et al.Dietary intake of total, animal, and plant proteins and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies.BMJ 2020;https://www.bmj.com/content/370/bmj.m2412

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    2021-05-13 gaoxiaoe
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objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Fri Jul 24 23:19:30 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804265, encodeId=72d080426539, content=学到了,多吃植物蛋白, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Jul 24 10:20:44 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804219, encodeId=20e480421979, content=低碳饮食有哪些不好的影响,最近在减肥😜, beContent=null, objectType=article, channel=null, level=null, 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  5. 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level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Jul 25 11:55:15 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498755, encodeId=63441498e55eb, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sat Jul 25 11:55:15 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804394, encodeId=39f180439401, content=植物蛋白, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Fri Jul 24 23:19:30 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804265, encodeId=72d080426539, content=学到了,多吃植物蛋白, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Jul 24 10:20:44 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804219, encodeId=20e480421979, content=低碳饮食有哪些不好的影响,最近在减肥😜, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/02/28/889a1910ded7780f3c049b354f1648b7.jpg, createdBy=2a791737770, createdName=mswert122, createdTime=Thu Jul 23 23:38:25 CST 2020, time=2020-07-23, status=1, ipAttribution=)]
    2020-10-22 xuyong535
  6. 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  7. 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  8. 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likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/02/28/889a1910ded7780f3c049b354f1648b7.jpg, createdBy=2a791737770, createdName=mswert122, createdTime=Thu Jul 23 23:38:25 CST 2020, time=2020-07-23, status=1, ipAttribution=)]
    2020-07-24 1240394fm61暂无昵称

    植物蛋白

    0

  9. 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level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Jul 25 11:55:15 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498755, encodeId=63441498e55eb, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sat Jul 25 11:55:15 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804394, encodeId=39f180439401, content=植物蛋白, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b972455532, createdName=1240394fm61暂无昵称, createdTime=Fri Jul 24 23:19:30 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804265, encodeId=72d080426539, content=学到了,多吃植物蛋白, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Fri Jul 24 10:20:44 CST 2020, time=2020-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804219, encodeId=20e480421979, content=低碳饮食有哪些不好的影响,最近在减肥😜, beContent=null, objectType=article, channel=null, level=null, 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    2020-07-24 Jessica

    学到了,多吃植物蛋白

    0

  10. 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likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/02/28/889a1910ded7780f3c049b354f1648b7.jpg, createdBy=2a791737770, createdName=mswert122, createdTime=Thu Jul 23 23:38:25 CST 2020, time=2020-07-23, status=1, ipAttribution=)]
    2020-07-23 mswert122

    低碳饮食有哪些不好的影响,最近在减肥😜

    0

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