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Diabetes Res Clin Pract:严重低血糖是糖尿病肾病的独立危险

2015-05-31 沐晴 MedSci原创

目的:研究认为低血糖与糖尿病微血管病变相关,因此本研究能够旨在评估严重低血糖在2型糖尿病肾功能不全的影响。 <span style="font-size:10.5pt;mso-bidi-font-family: Helvetica;color:#2F2F33;text-transform:uppercase;font-weight:normal">方法:研究选择在一家大型的三级医院,选择2

目的:研究认为低血糖与糖尿病微血管病变相关,因此本研究能够旨在评估严重低血糖在2型糖尿病肾功能不全的影响。

方法:研究选择在一家大型的三级医院,选择2004年-2013年间的门诊病例进行回顾性队列研究。一共筛选出101名2型糖尿病门诊患者入组,这些患者既往均发生过严重低血糖。另筛选101名2型糖尿病,无低血糖病史患者作为对照,对照组患者的血肌酐、年龄、性别、糖尿病病程作为对照基线。

结果:在合并低血糖和严重低血糖组,血肌酐水平(1.42±0.75mg/dL)显著的增加至1.77±1.26和 1.93±1.54mg/dL,基础eGFR(44.37±26.13ml/min/1.73m2下降至41.28±27.70和37.64±24.54ml/min/1.73 m2;然而在未合并低血糖组未观察到这种差异。

多元线性回归分析显示,严重低血糖对所有2型糖尿病来说,都是血肌酐水平上升和eGFR下降的独立危险因素;而且,在存在严重低血糖的T2DM组,基础肌酐水平、糖尿病病史长、低HbA1c,都是加剧肾损害的危险因素。

结论:严重低血糖与糖尿病肾病患者的肾功能恶化显著相关,基础肌酐水平高、糖尿病病史长的患者更容易加剧出现肾功能不全。

原始出处:


Lee YL1, Chen BK2, Lin KD1, Su RW3, Lee MY1, Hsiao PJ4, Shin SJ5.The impact of severe hypoglycemia on renal impairment in type 2 diabetes.Diabetes Res Clin Pract. 2015 Jun;108(3):448-55. doi: 10.1016/j.diabres.2015.02.028. Epub 2015 Mar 3.

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    2015-07-29 sundong

    严重低血糖又该如何判断呢

    0

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    2015-06-25 nizongzan

    高低都不好

    0

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    2015-06-25 nizongzan

    好不好?

    0

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  8. [GetPortalCommentsPageByObjectIdResponse(id=1685691, encodeId=670f1685691d9, content=<a href='/topic/show?id=f05d21150d1' target=_blank style='color:#2F92EE;'>#严重低血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21150, encryptionId=f05d21150d1, topicName=严重低血糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1428252752, createdName=fmq_28614562, createdTime=Mon Jan 25 18:56:00 CST 2016, time=2016-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759564, encodeId=2c7d1e595642d, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Sat Apr 23 01:56:00 CST 2016, time=2016-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901296, encodeId=533a1901296db, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Thu Dec 24 16:56:00 CST 2015, time=2015-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33719, encodeId=d52733e1918, content=严重低血糖又该如何判断呢, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Wed Jul 29 10:31:00 CST 2015, time=2015-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28821, encodeId=14112882177, content=高低都不好, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Jun 25 09:43:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28822, encodeId=b8a528822d4, content=好不好?, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded71629504, createdName=nizongzan, createdTime=Thu Jun 25 09:43:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1637117, encodeId=df49163e11728, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Jan 29 18:56:00 CST 2016, time=2016-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26606, encodeId=e2ed2660678, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=184, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Tue Jun 09 17:49:00 CST 2015, time=2015-06-09, status=1, ipAttribution=)]
    2015-06-09 ljjj1053

    认真学习了

    0

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