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A&R:娱乐性体育活动和膝骨关节炎的风险:个体参与者数据的国际荟萃分析

2022-04-21 MedSci原创 MedSci原创

娱乐活动期间的全身性、生理性能量消耗和体力活动时间与膝关节骨性关节炎结果无关。

     目的:体育活动对患膝关节骨性关节炎(OA)的风险尚不清楚。研究人员用这项研究,通过使用具有可比性的身体活动定义和OA定义来探究休闲体育活动与膝关节OA结果之间的关系。

    方法:数据来自6个全球、以社区为基础的患有和未患有膝关节OA的参与者队列(见下图)。符合条件的参与者在基线时没有膝关节OA或类风湿性关节炎。对参与者进行了5-12年的随访,结局指标包括以下内容:1) 影像学膝关节OAKellgren-Lawrence [K/L]2 级),2)疼痛性影像学膝关节OA(影像学OA伴有膝关节疼痛),以及3) OA相关的膝关节疼痛。自我报告的休闲体育活动包括运动和步行/骑自行车活动,并在基线时量化为每周几天的任务代谢当量(MET)。使用个体参与者数据荟萃分析计算和汇总风险比(RR)。次要分析评估了体育活动(定义为娱乐性体育活动所花费的时间(每周小时数)与膝关节OA结果之间的关联。

     结果:基于总共5065名参与者,汇总RR估计每周MET天数与疼痛性放射学OA的关联(RR 1.02 [95% 置信区间 (95% CI) 0.931.12]),与放射学OA的关联 (RR 1.00 [95% CI 0.941.07])及与OA相关的膝关节疼痛关联均不具有统计学差异(RR 1.00 [95% CI 0.961.04]。同样,每周花在体育活动上的小时数的分析也显示与所有结果没有显著关联

     结论:此研究结果表明,娱乐活动期间的全身性、生理性能量消耗和体力活动时间与膝关节OA结果无关。

 

出处:Gates, L.S., Perry, T.A., Golightly, Y.M., et al. (2022), Recreational Physical Activity and Risk of Incident Knee Osteoarthritis: An International Meta-Analysis of Individual Participant–Level Data. Arthritis Rheumatol, 74: 612-622. https://doi.org/10.1002/art.42001

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    2022-10-16 venlin
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    2023-02-06 lisa438
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    2022-04-22 lmm397
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