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Cell Metab:人造甜味剂让我们食欲大增

2016-07-18 佚名 生物谷

大量的研究表明,糖类替代物尽管比糖本身含有更少的能量,但是它们能够造成各种代谢紊乱,比如增加糖尿病风险,也许正好相反,长期使用糖类替代物会导致体重增加。上周二最新发表在Cell Metabolism上的研究报道人造甜味剂会模拟大脑的饥饿状态,从而导致大量饮食以满足其它器官的能量需求。 本研究是由来自悉尼大学Charles Perkins中心和Garvan医学研究所的科学家合作完成的。在他们的研究中

大量的研究表明,糖类替代物尽管比糖本身含有更少的能量,但是它们能够造成各种代谢紊乱,比如增加糖尿病风险,也许正好相反,长期使用糖类替代物会导致体重增加。上周二最新发表在Cell Metabolism上的研究报道人造甜味剂会模拟大脑的饥饿状态,从而导致大量饮食以满足其它器官的能量需求。

本研究是由来自悉尼大学Charles Perkins中心和Garvan医学研究所的科学家合作完成的。在他们的研究中,果蝇被喂食酵母和蔗糖或者通常用于低热量食物的人造甜味剂三氯蔗糖。喂食了无糖饮食的果蝇在接下来的5天或者更长时间比喂食了糖类食物的果蝇要多消耗30%的能量。当将三氯蔗糖从食物中去除,无糖组的果蝇的能量消耗又会降到正常水平。 

研究者使用一种被称作喙延伸应答(PER)的方法来进行研究,这种方法本质上是一种味觉测试,它能够帮助判断果蝇喜欢摄食某种特定的食物。通过这些方法,研究者发现三氯蔗糖的消耗会导致果蝇更倾向于摄入真正的糖类。此外,研究者还通过记录果蝇的味觉感受器电生理信号,发现延长三氯蔗糖的饮食时间似乎会增加昆虫对糖类的敏感程度。基因组研究副教授Greg Neely在邮件中解释道:"在持续摄入人造甜味剂后,动物能够感受到更低浓度的糖类,也会吃更过的糖,并且在生理上有更强烈的反应"。 

通过监测食欲和能量调节化合物如酶或神经递质的表达及其效应,Neely和他的同事能够勾勒出大脑中负责人造甜味剂诱导的饥饿效应的神经网络。Neely说他们发现在大脑的奖励中心甜味感觉与能量满足被整合到了一块。当甜味和能量失衡后,大脑会重新校准并且增加总能量的消耗。换句话说,当大脑只检测到甜味但是却未检测到实际的能量,它便会令糖类变得更加的可口,从而驱动了食物摄入量的增加。这些通路实际上是饥饿应答的一部分,它会使我们在饥饿的时候觉得食物更加的美味。 

Neely的发现似乎并不仅仅局限于果蝇。他的团队在小鼠身上重复了这些发现。啮齿类动物在摄入三氯蔗糖7天后,它们的食物摄入量增加了50%,这种现象部分是由被称为神经肽Y的神经递质所引起的。但是现在将这些结论应用到人身上还为时过早。 

目前,合成糖类在某种程度上对代谢有害的证据越来越显著。发表于2014年Nature杂志上的研究报道人造甜味剂能够改变小鼠和人肠道中微生物的类群从而促进了能量的吸收。最近的研究也发现了三氯蔗糖的摄取会损害人体处理正常糖类的能力。正如《科学美国人》今年早些时候报道的,过度食用甜的油腻的食物会改变大脑奖励系统中的脑化学,从而驱使我们过量饮食。

从这些研究中我们知道人造甜味剂三氯蔗糖并不是完全无效的,这也驱使更多的研究者去研究人造甜味剂是如何影响我们人本身的。

原始出处

How Artificial Sweeteners May Cause Us to Eat More

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    2016-11-28 一闲
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    2016-10-04 维他命
  4. [GetPortalCommentsPageByObjectIdResponse(id=1869472, encodeId=144b18694e293, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Mar 14 11:36:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895931, encodeId=0f1c1895931bc, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Nov 28 22:36:00 CST 2016, time=2016-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959730, encodeId=ec8a1959e30c1, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Oct 04 22:36:00 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887546, encodeId=f77d188e54651, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Dec 14 03:36:00 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708069, encodeId=08b61e0806993, content=<a href='/topic/show?id=e00b251e5dc' target=_blank style='color:#2F92EE;'>#人造#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25175, encryptionId=e00b251e5dc, topicName=人造)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48aa31545372, createdName=zjshifan_98647316, createdTime=Tue Mar 21 22:36:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447092, encodeId=77d5144e092c3, content=<a href='/topic/show?id=975010100260' target=_blank style='color:#2F92EE;'>#食欲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101002, encryptionId=975010100260, topicName=食欲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SpcCrdwMXJSYUAG0eoicES3DbgMdjibhYzPShfjJHlHFdRicDAdug8NtPOdBbaYAuYOd50130Q7aibsD2YyL8YvQ2g/132, createdBy=166d5313584, createdName=yeye5224614, createdTime=Wed Jul 20 10:36:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93571, encodeId=291f935e150, content=还好不怎么吃零食……, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xwU6047w4GQZHmaJMe3cGxCqPS0x43a9R04dN3HrAn5diaR2N4pEwoibqiaiaA3m6ia3g3XbZXadIomlRa5WAvjSUHb/0, createdBy=93aa1715091, createdName=为啥子, createdTime=Tue Jul 19 12:39:00 CST 2016, time=2016-07-19, status=1, ipAttribution=)]
    2016-12-14 guojianrong
  5. [GetPortalCommentsPageByObjectIdResponse(id=1869472, encodeId=144b18694e293, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Mar 14 11:36:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895931, encodeId=0f1c1895931bc, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Nov 28 22:36:00 CST 2016, time=2016-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959730, encodeId=ec8a1959e30c1, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Oct 04 22:36:00 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887546, encodeId=f77d188e54651, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Dec 14 03:36:00 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708069, encodeId=08b61e0806993, content=<a href='/topic/show?id=e00b251e5dc' target=_blank style='color:#2F92EE;'>#人造#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25175, encryptionId=e00b251e5dc, topicName=人造)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48aa31545372, createdName=zjshifan_98647316, createdTime=Tue Mar 21 22:36:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447092, encodeId=77d5144e092c3, content=<a href='/topic/show?id=975010100260' target=_blank style='color:#2F92EE;'>#食欲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101002, encryptionId=975010100260, topicName=食欲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SpcCrdwMXJSYUAG0eoicES3DbgMdjibhYzPShfjJHlHFdRicDAdug8NtPOdBbaYAuYOd50130Q7aibsD2YyL8YvQ2g/132, createdBy=166d5313584, createdName=yeye5224614, createdTime=Wed Jul 20 10:36:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93571, encodeId=291f935e150, content=还好不怎么吃零食……, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xwU6047w4GQZHmaJMe3cGxCqPS0x43a9R04dN3HrAn5diaR2N4pEwoibqiaiaA3m6ia3g3XbZXadIomlRa5WAvjSUHb/0, createdBy=93aa1715091, createdName=为啥子, createdTime=Tue Jul 19 12:39:00 CST 2016, time=2016-07-19, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1869472, encodeId=144b18694e293, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Mar 14 11:36:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895931, encodeId=0f1c1895931bc, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Nov 28 22:36:00 CST 2016, time=2016-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959730, encodeId=ec8a1959e30c1, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Oct 04 22:36:00 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887546, encodeId=f77d188e54651, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Dec 14 03:36:00 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708069, encodeId=08b61e0806993, content=<a href='/topic/show?id=e00b251e5dc' target=_blank style='color:#2F92EE;'>#人造#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25175, encryptionId=e00b251e5dc, topicName=人造)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48aa31545372, createdName=zjshifan_98647316, createdTime=Tue Mar 21 22:36:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447092, encodeId=77d5144e092c3, content=<a href='/topic/show?id=975010100260' target=_blank style='color:#2F92EE;'>#食欲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101002, encryptionId=975010100260, topicName=食欲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SpcCrdwMXJSYUAG0eoicES3DbgMdjibhYzPShfjJHlHFdRicDAdug8NtPOdBbaYAuYOd50130Q7aibsD2YyL8YvQ2g/132, createdBy=166d5313584, createdName=yeye5224614, createdTime=Wed Jul 20 10:36:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93571, encodeId=291f935e150, content=还好不怎么吃零食……, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xwU6047w4GQZHmaJMe3cGxCqPS0x43a9R04dN3HrAn5diaR2N4pEwoibqiaiaA3m6ia3g3XbZXadIomlRa5WAvjSUHb/0, createdBy=93aa1715091, createdName=为啥子, createdTime=Tue Jul 19 12:39:00 CST 2016, time=2016-07-19, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1869472, encodeId=144b18694e293, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Mar 14 11:36:00 CST 2017, time=2017-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895931, encodeId=0f1c1895931bc, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Mon Nov 28 22:36:00 CST 2016, time=2016-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959730, encodeId=ec8a1959e30c1, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Oct 04 22:36:00 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887546, encodeId=f77d188e54651, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Dec 14 03:36:00 CST 2016, time=2016-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708069, encodeId=08b61e0806993, content=<a href='/topic/show?id=e00b251e5dc' target=_blank style='color:#2F92EE;'>#人造#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25175, encryptionId=e00b251e5dc, topicName=人造)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48aa31545372, createdName=zjshifan_98647316, createdTime=Tue Mar 21 22:36:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447092, encodeId=77d5144e092c3, content=<a href='/topic/show?id=975010100260' target=_blank style='color:#2F92EE;'>#食欲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101002, encryptionId=975010100260, topicName=食欲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/SpcCrdwMXJSYUAG0eoicES3DbgMdjibhYzPShfjJHlHFdRicDAdug8NtPOdBbaYAuYOd50130Q7aibsD2YyL8YvQ2g/132, createdBy=166d5313584, createdName=yeye5224614, createdTime=Wed Jul 20 10:36:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93571, encodeId=291f935e150, content=还好不怎么吃零食……, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xwU6047w4GQZHmaJMe3cGxCqPS0x43a9R04dN3HrAn5diaR2N4pEwoibqiaiaA3m6ia3g3XbZXadIomlRa5WAvjSUHb/0, createdBy=93aa1715091, createdName=为啥子, createdTime=Tue Jul 19 12:39:00 CST 2016, time=2016-07-19, status=1, ipAttribution=)]
    2016-07-19 为啥子

    还好不怎么吃零食……

    0

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