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Dig Dis Sci:酒精相关性肝病患者的血清和粪便氧化物中氧脂素含量的变化

2019-07-06 不详 MedSci原创

酒精相关性肝病是全世界最常见的慢性肝病之一。氧脂素(Oxylipins)在许多生物化学过程和病理发病中起着至关重要的作用。然而,氧脂素在酒精相关的肝病中的相关发病机制没有得到很好的研究。因此,本项研究旨在探究(1)未使用酒精和酒精性肝炎患者生物活性ω-3和ω-6多不饱和脂肪酸代谢物的模式;(2)确定酒精相关性肝病患者血清氧脂素与临床参数的关系。

背景
酒精相关性肝病是全世界最常见的慢性肝病之一。氧脂素(Oxylipins)在许多生物化学过程和病理发病中起着至关重要的作用。然而,氧脂素在酒精相关的肝病中的相关发病机制没有得到很好的研究。因此,本项研究旨在探究(1)未使用酒精和酒精性肝炎患者生物活性ω-3和ω-6多不饱和脂肪酸代谢物的模式;(2)确定酒精相关性肝病患者血清氧脂素与临床参数的关系。

方法
研究人员对患有酒精相关性肝病的患者的血清和粪便中的ω-6花生四烯酸,ω-3二十碳五烯酸和二十二碳六烯酸衍生的氧脂素(oxylipins)进行了全面的液相色谱-串联质谱(LC-MS / MS)分析。并进行了相关统计分析。

结果
本项研究结果显示,与非酒精性肝炎患者相比,酒精使用障碍和酒精性肝炎患者的血清氧脂素谱有显着改变。不同血清氧脂素水平与肠道通透性,天冬氨酸氨基转移酶,胆红素,白蛋白,国际标准化比率,血小板计数,脂肪变性,纤维化和终末期肝病评分模型之间的存在相关性,特别是,较高水平的血清氧脂素与白蛋白减少,肝脂肪变性增加,多形核浸润和90天死亡率显着相关。

结论
不同原因导致的肝病患者具有不同的血清氧脂素特征,氧脂素未来可能成为预测肝病发展的新型生物标志物。

原始出处:
Bei Gao. Et al. Serum and Fecal Oxylipins in Patients with Alcohol-Related Liver Disease. Digestive Diseases and Sciences.2019.

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    2019-07-08 Homburg

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