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J Intern Med:臭氧也是空气污染 也是看不见的杀手!

2018-05-24 林巧楠 环球医学网

这几年,PM家族引发的大气污染物早已经是臭名昭着,但还有一类大气污染我们可能知之甚少,那就是臭氧。我们知道万米高空的臭氧层是“地球卫士”,但地表的可就是另外一回事了!大家眼睛刺痛、呼吸不畅、咳嗽的时候,你可能会抱怨空气PM2.5污染这么严重!但不少人发现,即使在艳阳高照、天气晴好时,也会出现上述症状,其实是拜臭氧所赐。

这几年,PM家族引发的大气污染物早已经是臭名昭着,但还有一类大气污染我们可能知之甚少,那就是臭氧。我们知道万米高空的臭氧层是“地球卫士”,但地表的可就是另外一回事了!大家眼睛刺痛、呼吸不畅、咳嗽的时候,你可能会抱怨空气PM2.5污染这么严重!但不少人发现,即使在艳阳高照、天气晴好时,也会出现上述症状,其实是拜臭氧所赐。

早在很久以前,科学家就证明过多接触臭氧会导致肺部疾病、心血管疾病,增加相关疾病的死亡率。尽管目前已有大量的多中心研究评估了臭氧暴露与死亡的相关性,但在中国,却尚没有臭氧与死亡率相关性的国家多中心研究。

因此,科学家2013~2015年在中国34个县进行了一项研究,考察多了个臭氧指标对季节死亡率的急性影响。研究结果于2018年5月发表于《J Intern Med》上。

研究者使用各种指标(每日1h最大值、每日8h最大值和每日平均值),分析了中国10个城市中34个县2013~2015年短期臭氧暴露对总体(非偶然)和特定原因(循环和呼吸)死亡率的影响。

使用分布滞后非线性模型评估了特定县相对死亡率风险,并通过进行随机效应mete分析合并了特定县相对比率。

结果表明,在全年分析中,每日平均值增加10μg/m3、每日1h最大值和每日8h最大值的臭氧处于lag02时,相应的总体(非偶然)死亡率分别增加0.6%、0.26%和0.37%;循环系统相关死亡率分别增加0.66%、0.31%和0.39%;呼吸系统相关死亡率分别增加0.57%、0.11%和0.22%。

可见,与其他任何指标相比,在中国,臭氧带来的急性影响与日平均暴露量更密切相关。

除此之外,死亡原因不同,季节模式也不同。一般来说,季节模式与一年当中臭氧浓度最高的时间相一致(春天和夏天臭氧浓度更高)。

这是中国首项关注臭氧对健康影响的大规模多中心研究。研究者发现:(ⅰ)每日1h最大值、每日8h最大值和全年每日平均臭氧暴露的汇总估计值与所有死亡结局密切相关(全因死亡率、循环和呼吸相关死亡率);(ⅱ)季节模式与臭氧浓度最高的时间一致(春天和夏天臭氧浓度更高,死亡率更高);(ⅲ)总体来说,日平均臭氧暴露量的影响最大,每日1h最大值的臭氧暴露最低。

一般来说,地表臭氧,一部分来自于高空臭氧层流入,另一部分来自于土壤、闪电、生物排放等等,这些自然界本就存在的”天然臭氧”危害不大。而危害健康的臭氧主力军是“人工臭氧”。

人工臭氧主要来自工厂燃煤、机动车尾气、石油化工等会排放出一些污染物。这些矿物燃料燃烧过程中产生的氮氧化物会在空中四处飘浮,其中部分氧原子慢慢与空气中氧气分子结合,就会形成臭氧。晴空太阳照射还会加速这一化学反应。使地表臭氧浓度升高,从而对人体产生危害。臭氧的危害主要是其强氧化性可以破坏细胞壁!

灰蒙蒙的PM2.5虽然招人厌弃,但看不见的臭氧危害也不容小视!

原始出处:
Sun Q, Wang W, Chen C, et al.Acute effect of multiple ozone metrics on mortality by season in 34 Chinese counties in 2013-2015.J Intern Med. 2018 May;283(5):481-488. doi: 10.1111/joim.12724. Epub 2018 Jan 18.

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    2018-06-15 ann y

    臭氧也是空气污染 也是看不见的杀手!

    0

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    2018-06-15 ann y

    臭氧也是空气污染 也是看不见的杀手!

    0

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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Jun 03 06:05:18 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319571, encodeId=e7683195e1eb, content=学习谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Tue May 29 06:57:18 CST 2018, time=2018-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406930, encodeId=09b0140693097, content=<a href='/topic/show?id=f8d88639461' target=_blank style='color:#2F92EE;'>#臭氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86394, encryptionId=f8d88639461, topicName=臭氧)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/g?b=oidb&k=ibXWWwSRHML00iboFvP8drcw&s=100, createdBy=4e292579924, createdName=xuqianhua, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472603, encodeId=db8214e260344, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608839, encodeId=3e0416088399b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=)]
    2018-06-15 ann y

    臭氧也是空气污染 也是看不见的杀手!

    0

  4. 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href='/topic/show?id=f8d88639461' target=_blank style='color:#2F92EE;'>#臭氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86394, encryptionId=f8d88639461, topicName=臭氧)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/g?b=oidb&k=ibXWWwSRHML00iboFvP8drcw&s=100, createdBy=4e292579924, createdName=xuqianhua, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472603, encodeId=db8214e260344, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608839, encodeId=3e0416088399b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=)]
    2018-06-15 ann y

    臭氧也是空气污染 也是看不见的杀手!

    0

  5. 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createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608839, encodeId=3e0416088399b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=)]
    2018-06-15 ann y

    臭氧也是空气污染 也是看不见的杀手!

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Fri Jun 15 02:14:39 CST 2018, time=2018-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324257, encodeId=abb432425ec5, content=臭氧也是空气污染 也是看不见的杀手!, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Fri Jun 15 02:14:34 CST 2018, time=2018-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320984, encodeId=e80032098497, content=阅读了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Jun 03 06:05:18 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319571, encodeId=e7683195e1eb, content=学习谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Tue May 29 06:57:18 CST 2018, time=2018-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406930, encodeId=09b0140693097, content=<a href='/topic/show?id=f8d88639461' target=_blank style='color:#2F92EE;'>#臭氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86394, encryptionId=f8d88639461, topicName=臭氧)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/g?b=oidb&k=ibXWWwSRHML00iboFvP8drcw&s=100, createdBy=4e292579924, createdName=xuqianhua, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472603, encodeId=db8214e260344, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608839, encodeId=3e0416088399b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=)]
    2018-06-03 半夏微凉

    阅读了谢谢分享

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Fri Jun 15 02:14:39 CST 2018, time=2018-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324257, encodeId=abb432425ec5, content=臭氧也是空气污染 也是看不见的杀手!, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRrYOibkVibW9vAkCfb2F55aHjqMoqUVaF9fuXIMCxexawSOsicpbF7Ria7o54zPK65PodlkwhPrNhLhS/0, createdBy=12f71314239, createdName=ann y, createdTime=Fri Jun 15 02:14:34 CST 2018, time=2018-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320984, encodeId=e80032098497, content=阅读了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Jun 03 06:05:18 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319571, encodeId=e7683195e1eb, content=学习谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Tue May 29 06:57:18 CST 2018, time=2018-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406930, encodeId=09b0140693097, content=<a href='/topic/show?id=f8d88639461' target=_blank style='color:#2F92EE;'>#臭氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86394, encryptionId=f8d88639461, topicName=臭氧)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/g?b=oidb&k=ibXWWwSRHML00iboFvP8drcw&s=100, createdBy=4e292579924, createdName=xuqianhua, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472603, encodeId=db8214e260344, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608839, encodeId=3e0416088399b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=)]
    2018-05-29 大爰

    学习谢谢分享!!

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sun Jun 03 06:05:18 CST 2018, time=2018-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=319571, encodeId=e7683195e1eb, content=学习谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Tue May 29 06:57:18 CST 2018, time=2018-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406930, encodeId=09b0140693097, content=<a href='/topic/show?id=f8d88639461' target=_blank style='color:#2F92EE;'>#臭氧#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86394, encryptionId=f8d88639461, topicName=臭氧)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/g?b=oidb&k=ibXWWwSRHML00iboFvP8drcw&s=100, createdBy=4e292579924, createdName=xuqianhua, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472603, encodeId=db8214e260344, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608839, encodeId=3e0416088399b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat May 26 02:47:00 CST 2018, time=2018-05-26, status=1, ipAttribution=)]
    2018-05-26 xuqianhua
  9. 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